Human gut microbiota plays an important role in maintaining human health. Many factors can disturb or alter the intestinal microbiota, resulting in intestinal dysbiosis and a number of health disorders. Modification of the gut microbiota has capable of promoting human health. Creative Biolabs offers high-quality service of antibiotic modification of gut microbiota to facilitate your microbe research.

Antibiotic

An Antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, which may either kill or inhibit the growth of bacteria. Besides, the limited number of antibiotics also possess antiprotozoal activity.

• Classification
  Antibiotics are commonly classified based on their mechanism of action, chemical structure, or spectrum of activity.
• Target the bacterial cell wall: penicillins and cephalosporins
• Target the cell membrane: polymyxins
• Interfere with essential bacterial enzymes: rifamycins, lipiarmycins, quinolones, and sulfonamides
• Protein synthesis inhibitors: macrolides, lincosamides, and tetracyclines
• Further categorization is narrow-spectrum antibiotics and broad-spectrum antibiotics
• Four new classes of antibiotics: glycylcyclines (tigecycline), cyclic lipopeptides (daptomycin), oxazolidinones (linezolid), and lipiarmycins (fidaxomicin).

Fig.1 Molecular targets of antibiotics on the bacteria cell. (Wikipedia)

• Usage
  Medical usage: Antibiotic is used to treat or prevent bacterial infections and protozoan infections (non-complicated acute appendicitis, pneumonia).
• Routes of administration: Take by mouth, intravenously, injection, or topical use.
• Global consumption: Consumption of antibiotics widely varies between countries.
• Side Effect
• Oral antibiotic: Diarrhea
• Interaction with other drugs: Systemic corticosteroid
• Mitochondrion damage
• Allergic reactions: Photodermatitis and anaphylaxis

Fig.2 Mechanisms of action of antibiotics and fecal microbiota transplantation (FMT). (Fong, 2020)

Antibiotic Modification of Gut Microbiota

Creative Biolabs offers antibiotic modification of gut microbiota to achieve the depletion of deleterious bacteria in vivo models.

• Antibiotic eradicates Fusobacterium colonization, and reduces colorectal cancer (CRC) proliferation in mice bearing CRC xenograft.
• Antibiotic reduces bacterial load in tumor and inhibits tumor invasion in mice with or without neutrophil depletion.
• Gut microbiome depletion by antibiotics elicits an antitumor immune response and suppresses tumor growth in metastatic mouse models.

Key Impact Factors of Antibiotic Modification Service

• Host defense mechanisms
• Location of infection
• Pharmacokinetic and pharmacodynamic properties of the antibacterial
• Antibacterial activity of the antibacterial

Creative Biolabs is committed to providing comprehensive and professional microbiota-related services or products to meet all the needs of our customers. For more information on our Gut Microbiota Engineering Service, please feel free to contact us for further discussion.

Reference

1. Fong, W.; et al. Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer. Oncogene. 2020, 4925-4943.

For Research Use Only | Not For Clinical Use