An imbalance in the gut microbiota promotes the progress of colorectal carcinogenesis. There are several therapeutic methods to alter the composition and the activity of gut microbiota, such as the administration of antibiotic, prebiotics, probiotics, and synbiotics. Creative Biolabs offers a full comprehensive gut microbiota engineering services to modify the composition of gut microbiota, improving intestinal dysbiosis consequently.

Gut Microbiota and Colorectal Cancer

Colorectal cancer (CRC) is the third most common cancer worldwide. CRC can be classified into two typical types according to genomic mutation diversity: colitis-associated colorectal cancer and sporadic colorectal cancer. There are several factors involved in the development of CRC, including eating habits, low level of physical activity, surgery treatment, infectious agents, and the administration of antibiotics. Many reports have shown an association between the composition of gut microbiota and the occurrence of CRC:

• Microbiota alterations induced by deoxycholic acid may promote the process of intestinal carcinogenesis.
• Butyrate (a kind of short-chain fatty acid) -activated T-regulatory cells reduce the production of pro-inflammatory cytokines, contributing to the prevention of CRC consequently.
• The fecal microbiome has been used as a tool for developing targeted non-invasive biomarkers for CRC.

Gut Microbiota Engineering

Due to the relation between the composition and activity of gut microbiota, there have been several therapeutic methods used to alter the gut microbiota and improve the therapy of CRC (shown in Fig.1).

Fig.1 Therapeutic methods of gut microbiota modification in CRC. (Kaźmierczak-Siedlecka, 2022)

As an excellent supplier at the forefront of science technology, Creative Biolabs has launched the gut microbiota engineering service platform. We integrate professional knowledge and experimental approaches from a series of subjects, including microbial physiology, microbial ecology, microbial biochemistry, enzymology, animal model development, toxicology, systems biology and environmental health, to help you gain a better understanding of the microbiome’s role in health and develop new methods to assess host-microbe interactions.

Featured Service

Antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections. Creative Biolabs offers antibiotic modification service of gut microbiota to facilitate your microbe research.

• Antibiotic Modification of Gut Microbiota
• Probiotic Modification of Gut Microbiota
  Probiotics are live microorganism. They provide health benefits when consumed, generally by improving or restoring the gut flora. Creative Biolabs offers prebiotic modification service of gut microbiota to facilitate your microbe research.
• Probiotic & Antibiotic Modification of Gut Microbiota
  Antibiotics and probiotics both modify the gut microbiota. Besides, they are both related with obesity, leading to weight loss. Creative Biolabs offers probiotic & antibiotic modification service of gut microbiota to facilitate your specific microbe research needs.
• Prebiotic Modification of Gut Microbiota
  Prebiotics are the compounds within food which induce the growth or activity of beneficial bacteria, such as bacteria and fungi. They can alter the composition of organisms in the gut microbiome in the gastrointestinal tract. Creative Biolabs offers prebiotic modification service of gut microbiota to facilitate your microbe research.
• Synbiotic Modification of Gut Microbiota
  Synbiotics are the mixtures of probiotics and prebiotics. They selectively stimulate the growth and/or by activating the metabolism of one or a limited number of health-promoting bacteria. Creative Biolabs offers synbiotic modification service of gut microbiota to facilitate your microbe research.
• Targeted Modification of Gut Microbiota Communities Using Antibodies
  Creative Biolabs has developed a novel technology which employs antibodies raised specifically against selected particular protein markers from the target bacterial species.

Gut microbiota engineering is a unique strategy to design controlled and effective living therapeutics. Creative Biolabs is committed to providing comprehensive and professional microbiota-related services or products to meet all the needs of our customers. If you are interested in our gut microbiota engineering service, please contact us for any discussion about your gut microbiota engineering needs.

Reference

1. Kaźmierczak-Siedlecka, K.; et al. Therapeutic methods of gut microbiota modification in colorectal cancer management - fecal microbiota transplantation, prebiotics, probiotics, and synbiotics. Gut Microbes. 2020, 11(6): 1518-1530.

For Research Use Only | Not For Clinical Use