KO Cell Line Products

KO cell lines, also known as knockout cell lines, are cells that have had a specific gene or genes disrupted, silenced, or deleted using techniques such as RNA interference. These cell lines are used in research to study the function of specific genes and their impact on cellular processes. By comparing the behavior of knockout cells to wild-type cells, researchers can gain insight into the role of genes in various biological pathways and disease processes. KO cell lines have been instrumental in advancing our understanding of gene function and in the development of new therapeutic strategies.

Advantages of KO Cell Lines

Reliable and consistent gene knockout

KO cell lines provide a reliable and consistent model for studying gene function by removing the expression of specific genes of interest.

Increased efficiency in research

KO cell lines help you save time and resources that would be otherwise spent generating and validating knockout models independently.

Simplifies gene function studies

KO cell lines simplify the process of determining the function of a specific gene by directly studying the effects of its absence on cellular processes.

Improved reproducibility

Using KO cell lines ensures that experiments are reproducible, as the same genetic modifications are present in all cells used in the study.

Facilitates drug discovery

KO cell lines can be used in drug discovery studies to screen potential therapeutics and determine how the absence of a specific gene affects drug response.

Opportunity for new insights

KO cell lines can be used to study the effects of gene knockout on cellular pathways, providing new insights into the function of genes and their role in disease.

Featured Products

Cat. NO	Product Name	Target	Applications
ITS-0822-HMM98	PharmaOnco™ B2M Knockout Jurkat Cell Line	B2M Knockout	Immunotherapy Research
ITS-0822-HMM207	PharmaOnco™ TCR Knockout Jurkat Cell Line	TCR Knockout	Immunotherapy Research
ITS-0822-HMM138	PharmaOnco™ FCGR2A(CD32A) Knockout Jurkat Cell Line	FCGR2A(CD32A) Knockout	Immunotherapy Research

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Applications of KO Cell Lines

Studying gene function
Investigate the function of a specific gene by observing how its absence affects cellular processes such as growth, differentiation, metabolism, and signaling pathways.
Drug discovery and development
Screen potential drug candidates and study their effects on cells lacking a particular gene.
Disease modeling
Create cellular models of diseases in which a particular gene is mutated or dysfunctional.
Functional genomics
Used in large-scale functional genomic studies to identify genes that play key roles in specific biological processes or diseases.
Personalized medicine
Study how genetic variations in specific genes affect drug responses and disease susceptibility in different individuals.
Cell therapy development
Engineered to express or lack specific genes to enhance their suitability for cell therapy applications, such as tissue regeneration or cancer immunotherapy.

Target

B2M

FCGR2A(CD32A)

TCR

TCR/B2M

Workflow of KO Cell Lines

Published Data

Fig.1 Generation of AGO2 knockout cell lines. Fig.1 The figure above shows a schematic of the generation of AGO2 knockout cell lines.¹

Contact Us for More

If you're looking for KO cell line products, lstatic/img/2-1-4-1-ko-cell-lines-3.jpgook no further! Creative Biolabs' team of experts specializes in providing tailored KO cell line solutions to meet your specific needs for immuno-oncology research. From design to delivery, our technical team is here to support you. If you can't find what you're looking for in our cell library, contact us now to learn more about how we can help you with your KO cell line requirements.

Reference

Schuster, S., Overheul, G.J., Bauer, L. et al. "No evidence for viral small RNA production and antiviral function of Argonaute 2 in human cells." Sci Rep 9, 13752 (2019). Distributed under Open Access license CC BY 4.0, without modification.