Cav2.2 Ion Channel

The Cav2.2 Calcium Channel, also known as the N-type calcium channel, is a type of voltage-gated calcium channel that is primarily found in neurons and cardiac tissue. The Cav2.2 Calcium Channel is a key player in neuronal communication and signaling, making it an important target for research and drug development in the field of neuroscience. Dysregulation of the Cav2.2 Calcium Channel has been implicated in various neurological disorders, including epilepsy, neuropathic pain, Parkinson's disease, arrhythmias, and changes in contractility. In drug development, assessing the potential effects of a drug on the Cav2.2 channel can be important for understanding its overall safety profile, especially if the drug has CNS activity or potential interactions with neuronal function.

Ion Channel Assay Services at Creative Biolabs

Calcium channel assays are indispensable in the safety assessment of new drug candidates. They enable researchers to identify potential cardiotoxic and neurotoxic effects early in the drug development process, ensuring only safe and effective drugs proceed through clinical trials. Creative Biolabs specializes in Cav1.2 and Cav2.2 calcium channel assays for high-throughput screening and detailed electrophysiological analysis of calcium channels. For Cav2.2 calcium channel assay, our experts use cutting-edge automated patch-clamp systems with HEK293 cells stably expressing Cav2.2 to provide a comprehensive understanding of a drug's impact on Cav2.2 channel function.

Assay Details

Creative Biolabs, we perform automated patch-clamp assays to gather high-quality electrophysiological data. Our team of experts is pleased to design customized assay protocols tailored to specific research needs.

• Automated Patch-Clamp Technique

• Automated versions of patch-clamp assay
• Measures ionic currents directly through calcium channels on cell membranes
• Provides detailed information on channel kinetics, conductance, and pharmacology

• Cell Model

HEK293 cells stably transfected with Cav2.2

• Test Concentration

1 or 6 concentration(s) are available. Specific concentration can be tailored to specific research needs.

• Data Delivery

Comprehensive reports provided with high-resolution data, analysis graphs, and conclusions.

Contact Us

Calcium channel assays are a vital component of in vitro ADME services, providing insights into the interactions between drug candidates and ion channels. These assays help ensure the safety and efficacy of new pharmaceuticals, guiding drug discovery and development processes. At Creative Biolabs, our skilled electrophysiologists and technicians bring extensive experience in both manual and automated patch-clamp techniques. To request our Cav2.2 calcium channel assay services or to learn more, please feel free to contact us. We look forward to collaborating with you on your research and drug development projects.

For Research Use Only | Not For Clinical Use