Ion Channel Assay Service for Toxicology Assessment

Ion Channels

Ion channels are transmembrane proteins that allow the passage of ions across cell membranes. These channels play a crucial role in cell signaling, muscle contraction, and nerve impulse propagation. Additionally, ion channels are important drug targets for a wide range of diseases, including neurological diseases, cardiovascular diseases, and cancer. Many drugs and compounds can interact with ion channels, either blocking or activating them, which can have significant effects on cell function and overall physiological processes. For example, drugs that block the hERG potassium channel can lead to QT prolongation, which is associated with an increased risk of cardiac arrhythmias and sudden death. Assessing how drugs modulate ion channel function is crucial for drug development and toxicology evaluation. Understanding the impact of a drug on particular ion channels enables researchers to predict potential adverse effects and develop more safer and efficient treatments.

Fig.1 Types of gated ion channels.¹

Ion Channel Assay Services at Creative Biolabs

Certain drugs may interact with ion channels in unintended ways, leading to toxic effects on the body. Ion channel assays are crucial for evaluating the impact of drugs on ion channels. Creative Biolabs provides ion channel assay service for testing and analysis of how drugs and compounds interact with ion channels in biological systems. This service provides a comprehensive understanding of how substances affect ion channel activity, helping in drug development, safety assessments, and mechanism of action studies. Our team has extensive experience working on various ion channel programs including calcium channel assays, sodium channel assays, Potassium channel assays, TRP channel assays, and HCN channel assays. Our collection of optimized stable ion channel cell lines is extensive and can be utilized for various ion channel assays and screening applications.

Our team offers:

• Ion Channel Binding
• Manual patch clamp
• Automated patch clamp
• Cell-based assays using FLIPR platform

Below you'll find channel assays according to different classifications of ion channels.

Benefits of Working with Us

• High-quality, cost-effective compound screening
• Expertise in ion channel electrophysiology and drug discovery
• A large collection of ion channels expressed in mammalian cells
• Rapid testing and detailed data interpretation by our experienced professionals

With specialized expertise, Creative Biolabs provides professional in vitro ADME services for cancer immunotherapy research. Our services cover a wide range of ADME assays, including metabolic stability, drug-drug interactions, kinetic solubility testing, and thermodynamic solubility testing. Contact us to explore how Creative Biolabs can assist in advancing your drug development projects.

Reference

1. Islam, Md Sirajul, James P. Gaston, and Matthew AB Baker. "Fluorescence Approaches for Characterizing Ion Channels in Synthetic Bilayers." Membranes 11.11 (2021): 857.

For Research Use Only | Not For Clinical Use