Cell Culture Process Development Services

Creative Biolabs is your reliable partners for developing high-productivity cell lines.

Our Services Advanced Technologies in Cell Culture Process Specificity and Optimization Late-stage Process Development and Scale-up Optimize Product Quality Applications Related Services
Cell Culture with Transparent Cell Dishes. (Creative Biolabs Authorized)

As a leader in the field of immunotherapy, Creative Biolabs has gained extensive experience developing mammalian and microbial production cell lines. The discovery experience coupled with our advanced analytical capabilities enables us to identify and select clones that meet your product's specific parameters and characteristics. After selecting the most appropriate clones, we optimize cell culture conditions to develop a high-productivity cell line tailored to your specific product quality targets and desired productivity level, which is designed for robust, scalable manufacturing.

Cell Culture Development Services

With a powerful team of over 100 dedicated and skillful scientists and technicians, Creative Biolabs offers state-of-the-art cell culture development services that support the entire bioprocess, from early-stage discovery through to manufacturing, including clone screening, media optimization, and bioreactor process control. Our cell culture development platform is dedicated to maximizing the expression, enhancing process reproducibility, and facilitating the future scale-up process. To ensure our cell culture development is highly professional, we are equipped with a wide range of cell culture systems as well as advanced testing technologies.

A Scientist uses Multi Pipette with Sample Preparation in the Laboratory Fume Hood for Bioassay. (Creative Biolabs Authorized)

Cell Status Was Examined by Microscopy. (Creative Biolabs Authorized)

Advanced Technologies in Cell Culture

Creative Biolabs employs cutting-edge technology to maximize productivity and process efficiency, offering clients innovative solutions at every development stage.

Precise process control

Regulation of dissolved oxygen (DO), pH, and nutrient levels.

Automation

Use of auto-instrument for high-throughput chromatographic screening.

Scalable platforms

Applications of both wave and rocker-based bioreactors, seamless transition from bench-top models to bioreactors up to 2,000 L.

Process Specificity and Optimization

Each cell culture project is customized to meet specific productivity and quality goals, leveraging Creative Biolabs' deep understanding of process parameters.

Media screening and adaptation

Optimization of nutrient profiles, osmolality, and byproducts.

Clone selection

Evaluation of growth rate, viability, and stability.

Optimized growth conditions

Temperature shifts, feed strategy, and environmental adjustments.

Late-stage Process Development and Scale-up

Creative Biolabs ensures smooth scale-up and regulatory compliance through advanced late-stage development strategies.

Tech transfer

Expertise in transferring processes from lab to manufacturing.

Process validation

Characterization studies to meet global regulatory standards.

Scalability

Process development from platforms to bioreactors up to 2,000 L.

Our advanced platform enables us to perform more than 30 simultaneous development projects at different development stages. We offer maximum flexibility to ensure your project is initiated at any stage of development. Any other requirements, please feel free to let us know.

Product Quality Optimization Solutions

Creative Biolabs offers a robust suite of solutions for optimizing product quality, ensuring that every biologic developed meets the highest regulatory and therapeutic standards. Our comprehensive approach focuses on both upstream and downstream strategies, with detailed attention to critical quality attributes (CQAs) that impact product efficacy, stability, and safety.

Applications of Cell Culture

Creative Biolabs' cell culture technologies are applied across various fields in biologics development, including:

Application Description Example
Monoclonal Antibody Production Development and production of antibodies that target specific proteins or cells to treat diseases such as cancer and autoimmune disorders. An antibody targeting HER2-positive breast cancer cells has significantly improved patient outcomes.
Biosimilar Development Creation of biologics that are highly similar to already approved drugs, ensuring comparable efficacy and safety. A biosimilar version of an anti-HER2 antibody was developed to reduce the cost of HER2-positive cancer treatments.
Vaccine Production Production of viral vaccines using cell-based systems to grow viruses or viral proteins. The use of Vero cells for producing the polio vaccine and SARS-CoV-2 vaccines highlights the importance of cell-based vaccine manufacturing.
Gene Therapy Using cells to produce viral vectors or gene-editing components for delivering therapeutic genes to patients. CAR-T cell therapies, which involve modifying a patient's T-cells to target cancer, exemplify the role of gene therapy in personalized medicine.

Tab.1 The Applications and Examples of Cell Culture-Based Technologies.

Each step in the upstream process impacts the quality, purity, and quantity of the manufactured protein. At Creative Biolabs, we have developed various mammal, bacteria, and yeast-based cell culture developments in the last decade, giving us the insight necessary to identify and optimize upstream parameters that are critical for achieving a high-quality, cost-effective biomanufacturing process. Please contact us for more information and a detailed quote.

Related Services

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