Cell Line Derived Xenografted Models

Cell line derived xenograft (CDX) models offer key decision-making information that allows the therapeutic candidates to move forward in preclinical testing for cancer immunotherapy development. To improve the cost-effectiveness and timeliness of sponsored preclinical development projects, Creative Biolabs has established multiple in vivo analysis systems with various CDX models to evaluate the candidates’ mechanism of action, PD/PK profiles.

Fig.1 Xenograft models. (Kohnken, Pierluigi & Anjali, 2017)

Fig.1 Cell line-derived and patient-derived xenograft mode.¹

Generation of CDX Models

Well characterized cell line derived xenografts cover the following types for your research:

✔ Subcutaneous model,
✔ Intravenous model,
✔ Orthotopic model,
✔ Metastasis model,
✔ Systemic model.

Our Validated CDX Models

Creative Biolabs has established over 200 validated and well-characterized CDX models as well as luciferase-labeled CDX models, which ensures an easy model selection. CDX models cover the following cancer types, but not limited to these. Working with CBL gives you access to customized CDX models to fit your program.

Solid Tumors

■ Brain Cancer	■ Brest Cancer	■ Bone Cancer	■ Bladder Cancer	■ Cervical Carcinoma
■ Colorectal Cancer	■ Endometrium Cancer	■ Epidermoid Carcinoma	■ Gallbladder carcinoma	■ Gastric Carcinoma
■ Glioma	■ Head and neck Cancer	■ Liver Cancer	■ Lung Cancer	■ Melanoma
■ Mesothelioma	■ Nasopharyngeal Carcinoma	■ Neuroblastoma	■ Ovarian Cancer	■ Pancreatic Cancer
■ Prostate Cancer	■ Renal Carcinoma	■ Rhabdomyosarcoma	■ Sarcoma	■ Skin Cancer
■ Thyroid Cancer	■ Uterine	■ Vulva Cancer

Hematological Malignancies Models

■ Acute Lymphoblastic Leukemia	■ Acute Monocytic Leukemia	■ Acute Myeloid Leukemia	■ Acute Myeloblastic Leukemia
■ Acute Promyelocytic Leukemia	■ Chronic Myeloid Leukemia	■ Eosinophilic Leukemia	■ Erythro Leukemia
■ Histiocytic Lymphoma	■ Megakaryoblastic Leukemia	■ Multiple Myeloma	■ Non-Hodgkin Lymphoma
■ Lymphoma (B-cell)

Highlight Features

Our portfolio of CDX models are evaluated on a regular basis for response to standards of care which are available for combination studies design.

✔ User-friendly techniques as well as excellent repeatability;
✔ Various xenoplastic transplantation;
✔ Customized models.

If you need to build or order customized CDX model, please don’t hesitate to contact us.

Reference

Kohnken, Rebecca, Pierluigi Porcu, and Anjali Mishra. "Overview of the use of murine models in leukemia and lymphoma research." Frontiers in Oncology 7 (2017): 22.