The exquisite hormone sensitivity of MCF-7 through the expression of estrogen receptor (ER), makes it an ideal breast cancer model to study hormone response. Creative Biolabs offers state-of-the-art services for engineering the breast cancer cell MCF7 for self-destruction that meet your specific tumor research needs. Besides, we also offer immune reactivity assessment services and toxicity assessment services after engineering.

Breast Cancer Cell MCF7

Originally, MCF-7 is a breast cancer cell line isolated from a 69-year-old white woman. Prior to MCF-7, it was no chance for cancer researchers to obtain a mammary cell line that was capable of living longer than a few months. MCF-7 and two other breast cancer cell lines, named T-47D and MDA-MB-231, account for more than two-thirds of all abstracts reporting studies on breast cancer cell lines, which is concluded from a Medline-based survey. Discoveries from the MCF-7 cell line have fundamentally altered the course of breast cancer research and have contributed to improved patient outcomes.

Fig.1 MCF7 cells. (Wikipedia)

Characteristics of MCF7 Cells

• Primary tumor
• Originate from pleural effusion
• Estrogen receptors present
• Proliferative response to estrogens
• Presence of progesterone receptors
• No ERBB2 gene amplification
• Tumorigenic in mice; Estrogen supplementation (engrafted into the subcutaneous fat or mammary fat pad)
• Tumorigenic in mice without estrogen supplementation (engrafted intraductal)
• Luminal epithelial phenotype

Engineering Breast Cancer Cell MCF7 for Self-destruction

Creative Biolabs provides a service that exploits and manipulates MCF7 cells to promote anti-breast cancer immunity. This method does not directly stimulate the MCF7 cells within the tumor bed, thereby avoiding the risk of increasing MCF7 cell-dependent metastases. Self-destruction means the strategy which transfects overexpressed cytokines into cancer cells by different technologies, thereby achieving the purpose of engineering MCF7 cells. Besides, Creative Biolabs also offers Ex Vivo Immune Reactivity Assessment Service and Toxicity Assessment Services after engineering.

Fig.2 The workflow of engineering breast cancer cell MCF7 for self-destruction. (Creative Biolabs)

Our Services

Expert in cancer immunity, Creative Biolabs provides comprehensive services to help you. You can find the exact strategies and assays in the following units:

For more breast cancer cell lines for self-destruction, please visit the unit of Engineering Cancer Cells for Self-destruction.

With a team of scientists who come from different research backgrounds, Creative Biolabs guides you all the way from project inception to high-quality results. If you have interest, please do not hesitate to contact us.

Reference

1. Lee, A.V.; et al. MCF-7 cells--changing the course of breast cancer research and care for 45 years. J Natl Cancer Inst. 2015, 31;107(7): djv073.

For Research Use Only | Not For Clinical Use