BGC-823 was first reported as the human gastric adenocarcinoma cell line. However, the STR DNA analysis pattern of BCG-823 showed contamination with the HeLa cell line. Creative Biolabs offers state-of-the-art services for engineering the gastric cancer cell BGC-823 for self-destruction that meet your specific tumor research needs. Besides, we also offer immune reactivity assessment services and toxicity assessment services after engineering.

Gastric Cancer Cell BGC-823

Gastric cancer is the second most common malignant tumor in the world and generally has metastasis when clinically examined. It is necessary to develop animal models of gastric cancer for exploring the mechanisms of carcinogenesis and clinical treatment strategy. There are many animal models of various tumors established by orthotopic implantation techniques since the 1990s. Many researchers have constructed orthotopic models of gastric cancer with different methods. Based on previous research, the BGC-823 cell line is a general cell model to observe biological characteristics to aid preclinical trials and therapy strategies.

The BGC-823 cell line was first derived from a specimen from a male patient who was 62 years of age. This specimen was conserved at the Tumor Institute of Tianjin in China. The BGC-823 cell line is poorly differentiated. The BGC-823 gastric cancer cell line provides evidence for researchers to learn the biological differences between animal models from different gastric cancer cell lines, which can help them to choose an appropriate model to tailor their research.

Fig.1 Images of the results of Ki-67 immunohistochemical staining of BGC-823 cell line. (Yang, et al., 2015)

Engineering Gastric Cancer Cell BGC-823 for Self-destruction

Creative Biolabs provides a complete set of services that exploit and manipulate BGC-823 cell lines to promote anti-gastric cancer immunity. Self-destruction means the strategy which transfects overexpressed cytokines into cancer cells by different technologies, thereby achieving the purpose of engineering BGC-823 cells. This method does not directly stimulate the BGC-823 cell line, thereby avoiding the risk of increasing BGC-823 cell-dependent metastases. Besides, Creative Biolabs also offers Immune Reactivity Assessment services and Toxicity Assessment services after engineering.

Fig.2 The workflow of engineering gastric cancer cell BGC-823 for self-destruction. (Creative Biolabs)

Our Services

Expert in cell therapy and cancer immunity, Creative Biolabs provides comprehensive self-destruction services to help you complete your research. You can find the exact strategies and assays in the following units:

For more gastric cancer cell lines for self-destruction, please visit the unit of Engineering Cancer Cells for Self-destruction.

With a team of scientists who come from different research backgrounds, Creative Biolabs guides you all the way from project inception to high-quality results. If you have interest, please do not hesitate to contact us.

References

1. Li, Y.; et al. Characterization of gastric cancer models from different cell lines orthotopically constructed using improved implantation techniques. World journal of gastroenterology. 2012, 18(2): 136-143.
2. Yang, Y.; et al. Enhancement of radiation effects by ursolic acid in BGC-823 human adenocarcinoma gastric cancer cell line. PloS one. 2015, 10(7): e0133169.

For Research Use Only | Not For Clinical Use