The gastric cancer cell NCI-N87, a tumorigenic epithelial cell line, was derived from a metastatic site in the liver of a male patient with gastric carcinoma. Creative Biolabs offers state-of-the-art services for engineering the gastric cancer cell NCI-N87 for self-destruction that meet your specific tumor research needs. Besides, we also offer immune reactivity assessment services and toxicity assessment services after engineering.

Gastric Cancer Cell NCI-N87

The NCI-N87 cell line was established from human gastric carcinoma and forms a well-differentiated monolayer that expresses epithelial-type tight junctions (i.e., E- cadherin and ZO-1). It represents a physiologically relevant model of the gastric epithelium. The NCI-N87 cell line secretes gastric mucin-6 glycoprotein and becomes acid-resist- ant when incubated with solutions at pH 3 and higher, and has already been used to investigate gastric drug metabolism.

• Characteristics and applications of gastric cancer cell NCI-N87

✔ As a platform to test new drug candidates as well as predict in vivo drug responses in humans.

✔ Positively tested for myc and erb B2 oncogenes.

✔ Expresses carcinoembryonic antigen as well as TAG 72 surface glycoproteins.

✔ EGFR-positive, human epidermal growth factor receptor 2 (HER2) positive and responds to cetuximab as well as carboplatin both in vitro and in vivo.

✔ Establish a peritoneal gastric carcinoma xenograft model to support survival outcome analysis.

Fig.1 Immunocytochemistry images of NCI-N87 cells. (Conlin, et al., 2004)

Engineering Gastric Cancer Cell NCI-N87 for Self-destruction

Creative Biolabs provides the complete set of services that exploit and manipulate NCI-N87 cell lines to promote anti-gastric cancer immunity. Self-destruction means the strategy which transfects overexpressed cytokines into cancer cells by different technologies, thereby achieving the purpose of engineering NCI-N87 cells. This method does not directly stimulate the NCI-N87 cell line, thereby avoiding the risk of increasing NCI-N87 cell-dependent metastases. Besides, Creative Biolabs also offers Immune Reactivity Assessment services and Toxicity Assessment services after engineering.

Fig.2 The workflow of engineering gastric cancer cell NCI-N87 for self-destruction. (Creative Biolabs)

Our Services

Expert in cell therapy and cancer immunity, Creative Biolabs provides comprehensive self-destruction services to help you complete your research. You can find the exact strategies and assays in the following units:

For more gastric cancer cell lines for self-destruction, please visit the unit of Engineering Cancer Cells for Self-destruction.

With a team of scientists who come from different research backgrounds, Creative Biolabs guides you all the way from project inception to high-quality results. If you have interest, please do not hesitate to contact us.

Reference

1. Conlin, V.S.; et al. Helicobacter pylori infection targets adherens junction regulatory proteins and results in increased rates of migration in human gastric epithelial cells. Infection and immunity. 2004, 72(9): 5181-5192.

For Research Use Only | Not For Clinical Use