By partnering with the world's leading immuno-oncology scientists, Creative Biolabs has gained superior experience in preclinical and translational immuno-oncology. Use our ferroptosis-mediated crosstalk services to quickly identify the right targets for cancer immunotherapy. We offer a wide range of ferroptosis-mediated crosstalk analysis platforms, including core immunophenotypic, functional assay, and tumor microenvironment regulation, so you can proceed to the next stage of drug development with confidence.

Introduction to Ferroptosis-mediated Pathway

There are precise and complex interactions between tumor cells, immune cells, and stromal cells, and this "crosstalk" often requires some substances to make the connection between the cells closer. Ferroptosis has attracted a lot of attention in recent years. The complex interaction of ferroptosis and its related components and immune cells plays a crucial role in coordinating TME recombination, including processes such as angiogenesis, extracellular matrix (ECM) remodeling, and immune escape. Understanding the interaction between specific tumor types and ferroptosis could accelerate the development of new therapies.

As a repository of potential therapeutic targets, the tumor microenvironment has attracted considerable attention in cancer research. Recently, Creative Biolabs has developed a series of potential therapeutic target discovery solutions, such as targets that modulate tumor immune response, targets that indirectly activate immune response, targets that modulate stromal cell function, and key genes that directly alter extracellular matrix proteins in ferroptosis-mediated tumor microenvironment. Also, our transcriptional pattern analysis service in the tumor microenvironment covers important factors involved in the complex interaction of ferroptosis between the tumor, the microenvironment, and the cancer immune response, enabling the characterization and evaluation of the full spectrum of tumor biology and tumor immune escape mechanisms, respectively.

Fig.1 Crosstalk Between Ferroptosis And Tumor Immunity.¹

Services

The effect of ferroptosis-targeting cancer cells on their anti-tumor immunity will vary depending on tumor type and specific TMEs. Creative Biolabs provides a series of services on the immunogenicity of ferroptosis cancer cells, the effect of ferroptosis on immune cells, and the interaction between ferroptosis cells and anti-tumor immunity to help clients elucidate the regulatory role of ferroptosis in anti-tumor immunity and its mechanisms. Moreover, we can also help customers evaluate the feasibility and potential risks of ferroptosis-targeted tumor therapy, and provide the translational basis for selecting candidate targets for different types of tumors and developing novel immunotherapy strategies.

In addition, to further explore the communication network between immune cells in TME, Creative Biolabs has designed and collected multiple sets of single-cell sequencing data of TME, combined with the latest prediction algorithms and tools of intercellular communication, and attempted to analyze the signal communication network between different immune cells in TME, to reveal the coordination and development mechanism of tumor cell ferroptosis in the immune microenvironment.

Case Study

Up to now, Creative Biolab has identified the expression and the infiltration levels of various tumor antigens, such as PD-L1, CD8, CD45RO, FOXP3, and other TME cells using immune profiling. Furthermore, we have developed a CBLTM-sEQ platform capable of simultaneously performing full-length sequencing of multiple ferroptosis-related tumor molecules. In our labs, we can analyze the complete transcriptome of thousands of cells as well as data from hundreds of cell surface proteomes targeting tumor cell ferroptosis.

Creative Biolabs provides services for the analysis of ferroptosis-mediated crosstalk mechanisms between cancer cells and their surrounding tumor microenvironment. From cell selection, model construction, and expression detection, to data analysis, every step is scientifically and carefully designed to ensure high-quality data feedback. If you are interested in our services, please contact us or send us an inquiry.

Reference

1. Liu, Yini, et al. "Ferroptosis-mediated crosstalk in the tumor microenvironment implicated in cancer progression and therapy." Frontiers in cell and developmental biology 9 (2021): 739392.

For Research Use Only | Not For Clinical Use