Creative Biolabs is a CRO company focusing on ferroptosis innovation technology and translational application of oncology research. The core team has been deeply engaged in the field of cancer immunotherapy for nearly ten years, expanding the multi-dimensional business system in the fields of spatial omics, transcriptomics, microbiome, and other fields, and helping customers reveal new therapy opportunities for cancer.

Introduction to Ferroptosis-mediated Pathway

Ferroptosis presents a novel avenue for research in cancer therapy. Ferroptosis is implicated in the development of drug resistance in certain tumors plays a role in the treatment process of many cancer therapies and is an overlooked mechanism in tumor therapy. The intricate main mechanism and signaling pathway of ferroptosis are closely associated with the cystine/glutamate reverse transporter, glutathione peroxidase 4, ferroptosis suppressor protein 1, dihydrooriotic dehydrogenase, and other factors. Elucidating the ferroptosis pathway and its associated mechanism in regulating tumor development may offer novel insights for tumor therapy.

In Creative Biolabs, we offer a comprehensive range of products and services that explore ferroptosis-induced tumor signaling pathways and signal transduction to advance your research. It includes more than 300 high-quality ferroptosis-related proteins and a complete range of analytical products. We provide key proteins and research strategies for ferroptosis-related signaling pathways and provide a series of analysis solutions on the association and transformation of ferroptosis between multiple tumors.

Fig.1 Signaling Pathways Regulating Ferroptosis in Prostate Cancer.¹

Chief Solutions

To develop new tools for cancer immunotherapy in the context of specific ferroptosis-related pathways, Creative Biolabs offers two main technology platforms for high-throughput screening and analysis of endpoint or adjacent pathways. To choose the components needed for the right ferroptosis detection for your study, please use our new analytical tool. In our labs, we use a range of analytical methods, such as microscopy, flow cytometry, western blotting, PCR/qPCR, and next-generation sequencing (NGS) technologies to broaden the scope of tumor cell ferroptosis research, enabling data analysis across genomes, transcriptomes, and epigenomes.

Xc--GSH-GPX4 Pathway

Creative Biolabs offers modeling and validation services for tumor cell studies based on both antioxidant and non-antioxidant XC--GSH-GPX4 systems. On the one hand, we promote tumor therapy by inducing Xc- to reverse the inactivation of the transporter and the depletion of cystine in the process of ferroptosis. On the other hand, we can use the regulatory effect of FSP1-CoQ on nuclear factor E2-related factors to promote cellular lipid peroxidation to accelerate tumor cell ferroptosis.

Mitochondria-Targeting liposome System

We have developed a targeted liposomal system induced by ferroptosis, which selectively accumulates in mitochondria and deactivates DHODH, leading to mitochondrial lipid peroxidation in tumor cells. This process promotes the release of internal injury-related molecules (such as calcin, ATP, and high mobility group protein B1) to achieve tumor inhibition activities. Moreover, we have identified dozens of ferroptosis-related genes and several key genes associated with various types of tumors that can effectively predict the cancer prognosis.

• Realize comprehensive screening of ferroptosis signal pathway;
• Applicable to tissue, cell, and other types of samples;
• Low protein content can satisfy the experiment;
• Can provide both gene and protein level data;
• It can be used in humans, mice, rats, and other types of pattern detection.

Creative Biolabs is a top bio-company specializing in oncology and ferroptosis research. Based on the process of anti-tumor drug research and development, relying on various ferroptosis-related analysis model platforms, we provide customers with efficient oncology screening and ferroptosis detection services. If you are interested in our services, please contact us or send us an inquiry.

Reference

1. Zhao, Shankun, et al. "Roles of ferroptosis in urologic malignancies." Cancer cell international 21.1 (2021): 676.

For Research Use Only | Not For Clinical Use