Function of Venom Peptides

Animal venom is a mixture that contains highly toxic substances. It is made up of a variety of molecules such as amino acids, proteins, and peptides. Peptides and proteins are the main components, and studies have found that they can play a therapeutic role in a variety of diseases. At present, the development of venom peptides has become an emerging way of drug development.

Take bee venom as an example, a yellowish transparent venom whose main components include active enzymes, peptides, sugars, lipids, amino acids, and amines. Among them, bee venom peptide is an important component with strong pharmacological and biological activity in bee venom. The pharmacological effects of melittin have been studied including anti-inflammatory, analgesic, bactericidal, anti-tumor, blood pressure regulatory, anti-radiation, etc.

Fig.1 Different therapeutic effects of bee venom.¹

Venom peptides can exhibit different pharmacological functions and different biological activities due to their small structural differences. Through the continuous exploration of the structure of venom peptides and their corresponding functions, its active ingredients can be clarified and new drugs with efficacy can be further developed. Creative Biolabs has been committed to the development and research of venom peptides, and we provide customers with a full range of functional assays to discover and characterize the venom peptides’ functional efficacy in different diseases.

Our Services

Based on a deep understanding of venom peptides and an advanced technology platform, Creative Biolabs provides but is not limited to the following assays:

• Antiviral Activity

Bee venom peptide reduces the amount of HIV-1 production in T lymphoma cells persistently infected with human immunodeficiency virus 1 (HIV-1) in a dose-dependent manner. Bee venom peptide reduces viral infectivity through its intracellular action. Creative Biolabs offers a range of antiviral-related experiments to help you validate the functionality of molecules in venom.

• Antitumor activity

Venom peptides, such as bee venom, can inhibit the oxidative phosphorylation process of tumor tissues, thereby inhibiting tissue metabolism and playing an anti-tumor role. Creative Biolabs offers a range of assays to validate anti-tumor activity, providing you with a complete pipeline and reliable data results from in vivo to in vitro.

• Antibacterial Activity

Bee venom kills pathogenic bacteria in three ways: first, after bee venom is integrated into the plasma membrane, it forms vacuoles, causing the leakage of substances in the bacteria; the second is the plasmolysis, and the cell is lysed and dies; Third, the formation of vacuoles in cells can induce cytoplasmic cavities, which can lead to cell death. Creative Biolabs offers in vitro/in vivo bacteriostatic assays to provide a rationale for the antimicrobial activity of your venom peptides.

• Anti-inflammatory and Analgesic Activity

Ion channels play an important role in the sensation of pain mediated by diseases such as inflammation, arthritis, and migraine. Snake venom is a novel source of specific blockers and activators of ion channels. Creative Biolabs offers a range of ion channel-related assays to help you validate the activity development of relevant venom compounds. You can find more information at the Ion Channel Screening Service for Venom Peptide unit.

Features of Our Service

• Comprehensive
• Professional
• Reliable

Venom is an extraordinary library of bioactive compounds with great medicinal potential. Bioactive drugs can be developed through the study of the structure, function, chemical reactivity, and target identification of the components that make up the venom. Creative Biolabs provides you with a one-stop venom peptide development service, if you are interested in our venom peptide service, please contact us now.

Reference

1. Khalil, A.; et al. "Bee venom: from venom to drug." Molecules. (2021) 16 4941.

For Research Use Only | Not For Clinical Use