Venom Peptides

The original venom contains a variety of peptides, and many of them are bioactive. Venom peptides can bind to a variety of membrane protein channels and receptors. Chloride channel and potassium channel membrane proteins are overexpressed in different types of cancer. Therefore, it has a certain anti-cancer effect. For example, chlorotoxins isolated from scorpion Leiurus quinquestriatus can bind to certain tumors and gliomas as well as Ca²⁺ activated chloride channels.

Fig.1 Some typical venom peptides.¹

Venom Peptides for Cancer Immunotherapy

Venom-derived molecules have the ability to modulate immune cells directly as venom-derived compounds or as initial structures for drug development. There are many ways in which venom-derived molecules induce the immune system, such as regulating ion channels and influencing the cholinergic anti-inflammatory pathway. Therefore, Creative Biolabs introduces the new Venom Peptide Services Platform to accelerate the development of your immunomodulatory drugs.

Fig.2 The link between the immune system and venom compounds.²

Our Service

Creative Biolabs has extensive experience and a professional team in immunotherapy. For a long time, we have been committed to exploring the interaction between venom peptides and the immune system, constantly researching and developing new pathways or receptors, and developing venom-derived immunomodulatory drugs. In addition to provide you with high-quality venom peptides and their derivatives, we also offer a range of venom peptide-related services to accelerate your development research. Please browse the information below and click on what you are interested:

• Venom Peptides Synthesis Service
  Venom peptides have been shown to treat pain, cancer, diabetes, multiple sclerosis, cardiovascular disease, etc. After separating the peptides in the venom, large quantities of venom peptides can be obtained by synthesizing peptides. These peptides can be explored for the next step through structural elucidation, cellular or animal studies. Creative Biolabs has experts in peptide synthesis and recombinant peptide synthesis to provide you with professional knowledge and services for your venom peptide research.
• Toxicological Evaluation of Venom Peptides
  Creative Biolabs provides customized venom peptide toxicity testing services to simplify and accelerate the client's project process.
• Identified and Characterized of Venom Peptides
  Creative Biolabs has been committed to the development and research of venom peptides, providing reliable technical support and high-quality services for the isolation and characterization of your venom peptides through our professional platform and novel technologies.
• Ion Channel Screening Service for Venom Peptides
  Creative Biolabs tailors ion channel screening services to your target to meet your specific venom discovery needs. We provide you with powerful, reliable results, data and timely delivery to accelerate and validate your drug discovery program.
• Venom Peptide Delivery Optimization Service
  Venom peptides need to be stable enough to degrade or digest at ambient temperatures. By optimizing and modifying different sites of peptides, the stability of venom peptides can be improved. In addition, the use of venom peptides for drug delivery is also one of the current research hotspots. Creative Biolabs provides a variety of venom peptide optimization services, providing you with professional technical support and reliable solutions from different research directions.
• Function Assay for Venom Peptides
  Venom peptides can exhibit different pharmacological functions and different biological activities due to their small structural differences. Through the continuous exploration of the structure of venom peptides and their corresponding functions, its active ingredients can be clarified and new drugs with efficacy can be further developed. Creative Biolabs has been committed to the development and research of venom peptides, and we provide customers with a full range of functional assays to discover and characterize the venom peptides' functional efficacy in different diseases.

Application of Venom Peptides

Many venom peptides have been shown to treat pain, diabetes, cancer, multiple sclerosis, and cardiovascular disease.

Fig.3 Applications of venom peptides. (Creative Biolabs Original)

Prospect and Future

The development and study of venom-derived molecules have two therapeutic implications for the regulation of immune activity.

• A range of studies, from characterization to screening, can inform venom treatment strategies.
• The exploration of venom-immune effects is an important source for the discovery of new pathways/receptors and venom-derived immunomodulatory drugs.

Fig.4 Advantages and disadvantages of peptides.³

If you are interested in our Venom Peptide Services, please contact us now. Creative Biolabs' professionals are always here to help with your projects and needs!

References

1. Ageitos, Lucía.; et al. "Biologically active peptides from venoms: applications in antibiotic resistance, cancer, and beyond." International journal of molecular sciences. (2022) 23,23 15437.
2. Ryan, Y.M.; et al. "Immunological responses to envenomation." Frontiers in immunology. (2021) 12 661082.
3. Wang, L.; et al. "Therapeutic peptides: current applications and future directions." Sig Transduct Target Ther. (2022)

For Research Use Only | Not For Clinical Use