Human PBMC-B Mouse Model for Immuno-Oncology Study

Introduction

The advent of immunotherapy has revolutionized the landscape of cancer treatment, offering promise for malignancies that were previously deemed incurable. However, the translation of immunotherapeutic agents from bench to bedside faces significant hurdles due to species-specific differences in preclinical models. Humanized mouse models, particularly those utilizing human peripheral blood mononuclear cells (PBMCs), provide an invaluable platform for investigating human immune responses in tumor immunology. Creative Biolabs has developed the innovative Human PBMC-B Mouse Model to overcome these challenges and enhance the study of immuno-oncology in a clinically relevant manner.

Characteristics of the Human PBMC-B Mouse Model

The Human PBMC-B Mouse Model addresses critical limitations present in traditional murine models. Conventional models often fall short in replicating human immune responses due to species-specific differences and the lack of human antibody involvement. Our innovative model includes immunodeficient mice co-engrafted with human PBMCs and tumor cells, thereby providing a more physiologically relevant platform for human-specific immunotherapy research.

Our Human PBMC-B Mouse Model for Immuno-Oncology Study

Creative Biolabs offers a proprietary Human PBMC-B Mouse Model designed explicitly for the pre-clinical evaluation of tumor immunotherapies and autoimmune disease drugs. This model addresses the limitations of traditional PBMC and CD34+ hematopoietic stem cell (HSC) models by incorporating human antibody involvement in immune responses, thereby providing a more comprehensive and realistic system for immunotherapy research.

  • Human B-Cell Reconstruction

Our Human PBMC-B Mouse Model successfully reconstructs human B cells within immunodeficient mice. This enables the simulation of human immune responses that include human-specific antibody production, a critical feature often missing in other humanized models.

  • Enhanced Antibody Functionality

Compared to traditional CD34+ HSC models, the reconstructed B cells in our model possess active antibody secretion functionality. This enhancement generates richer and more relevant data for immuno-oncology research, making it an invaluable tool for researchers.

  • Complete Humoral Immunity Process

In conjunction with our human myeloid cell reconstruction model, the Human PBMC-B Mouse Model fully characterizes the entire humoral immune process—from antigen presentation and B-cell activation to antibody expression. This allows for a comprehensive understanding of immune responses during tumor development and treatment.

Features of the Human PBMC-B Mouse Model

The Human PBMC-B Mouse Model provides a more accurate simulation of human immune responses, including the secretion of human immunoglobulins (IgG), which begins around Day 22 post-PBMC injection.

Our model is suitable for a range of pre-clinical applications, including:

Assessment of immunotherapy efficacy and safety.

Elucidation of autoimmune disease mechanisms.

Evaluation of viral immune responses.

Exclusive Leading Technology

Built upon the latest research findings, our model stands as a unique technology of Creative Biolabs, offering cutting-edge technical support for various research endeavors.

Our team comprises scientists with years of expertise in the field, ensuring robust professional support. From model establishment to comprehensive data analysis, Creative Biolabs provides a one-stop service tailored to specific research needs.

Related Services

Our validated in vivo oncology models encompass mouse tumor allografts (syngeneic models), and human xenografts derived from both cell lines (CDX) and patient samples (PDX). These models are instrumental in evaluating the anti-cancer response of new testing agents.

We offer custom models to meet specific pharmacology needs, whether for efficacy testing or side-effect profiling. Our capabilities extend to small molecules, drug combinations, biologics, nucleic acids, liposomal formulations, nanoparticles, and vaccines.

Frequently Asked Questions

Q1: What advantages does the Human PBMC-B Mouse Model offer over traditional models?

A1: The Human PBMC-B Mouse Model includes active human antibody secretion and a full humoral immune response, providing richer and more relevant data compared to traditional PBMC and CD34+ HSC models.

Q2: How long can human B lymphocytes proliferate in the Human PBMC-B Mouse Model?

A2: Following the injection of PBMCs, human B lymphocyte proliferation can be detected in the mouse spleen for over 35 days, with IgG secretion starting around Day 22.

Creative Biolabs remains committed to advancing immuno-oncology research by providing state-of-the-art humanized mouse models and comprehensive support services. For more information, contact us to leverage our expertise and enhance your research outcomes.

For Research Use Only | Not For Clinical Use

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