Immunotoxicology - Creative Biolabs

To help you efficiently navigate the complicated biological landscape of immune system caused by cancer immunotherapy, Creative Biolabs offers immunotoxicological studies to facilitate your preclinical testing and move your program efficiently forward to IND approval and further market approval. Accurate analysis of the immunotoxicological study results are critical to describe the therapeutic or adverse effects on the immune system.

Immunotoxicology Service

Cancer immunotherapies are designed to modulate the immune system to treat cancer, improving our own natural ability to fight cancer. For unexpected consequences, we work closely with our clients with our expertise in immunotoxicology and immunology to isolate the adverse effects and push the program along the continuum. In Creative Biolabs, you can find a wide breadth of assays in immunotoxicology and immunology as biomarkers to monitor the potential safety risks and pharmaceutical efficacy via defining immune endpoints and changes in cell function.

Cell-based Assays

✔ Immunophenotyping assays in blood or tissues
✔ Functional assays using primary cells from multiple species
✔ Functional assays using established cell lines
✔ Immune response analysis

■ T cell dependent antibody response	■ Complement response	■ Proliferation	■ Natural killer (NK) cell activity
■ T cell cytotoxicity	■ ADCC/CDC	■ Basophil	■ Delayed-type hypersensitivity
■ Cytokine/Chemokine • Profiling • Release	■ Neutrophil/Macrophage • Oxidative burst activity • Phagocytosis • Migration	■ Immuno-biomarker analysis • Cell activation • Cell apoptosis • Receptor occupancy and candidate molecule binding

Whole Animal Studies

✔ Immunophenotyping assays (blood, tissues)
✔ Immunoassays (including T-dependent antibody responses)

Hypersensitivity Responses

✔ Complement response
✔ Murine local lymph node assay
✔ Guinea pig maximization test and Buehler test
✔ Histamine release assay
✔ IgE titration
✔ Antidrug antibody (ADA) assays
✔ Host resistance models
✔ Studies supporting vaccine and biologic development

Platform-based Approaches

✔ Flow cytometry
✔ ELISA, ELISpot and FluoroSpot
✔ Immunoassay
✔ Immunochemistry
✔ Immunohistochemistry

Highlights

✔ Immunotoxicology and immunology support for all cancer immunotherapies including small molecule and macromolecular therapeutics, cellular and gene therapies, and vaccines;
✔ An integrated solution combined with state-of-the-art technologies;
✔ High quality robust data delivered on-time, affordably.

In Creative Biolabs, we assist our clients to realize immunotherapy efficiency with our wide range of assays in preclinical studies to move your candidate drug or therapy along the continuum. Please contact us for more detailed information.