Infusion Toxicology Service

To mimic the clinical route of intravascular administration or to allow sufficient exposure for safety evaluation purposes, various infusion procedures are increasingly applied to drug discovery and development programs.

With extensive infusion expertise, experience and advanced capabilities, Creative Biolabs provides infusion toxicology studies to evaluate the potential risks caused by increasingly complex infusion procedures for pre-clinical toxicological studies.

Infusion Toxicology Service

Creative Biolabs has established intermittent and continuous infusion models to support your programs for both rodent and non-rodent species. To facilitate complicated and challenging study designs of our clients, we integrate our rich infusion experience with cutting-edge infusion technology to ensure superior quality and cost-effective solutions. With state-of-the-art surgical and delivery equipment, we offer a variety of innovative vascular infusion methods including 24/7 continuous infusion, slow bolus injection and intermittent infusion techniques. We cooperate with our clients in the following infusion functions.

We collaborate closely with divisions within Creative Biolabs to conduct infusion toxicology studies with integrated comprehensive endpoints, resulting in robust fit-for-purpose solutions to our clients’ infusion needs.

Specialized Assessments

• ■ Cardiovascular monitoring by radiotelemetry
• ■ Cardiac biomarker profiling
• ■ Neurological assessments
• ■ Reproductive assessments
• ■ Cerebrospinal fluid (CSF) sampling
• ■ Vitreous and ocular tissue sampling
• ■ Terminal whole-body perfusion
• ■ Specialized histopathology techniques

Animal models include rats, rabbits, ferrets, canines, and nonhuman primates.

Highlights

To support cancer immunotherapy, Creative Biolabs offers infusion administration into tumor-bearing animal models for efficacy studies, sampling and dosing through double vessel catheters and peritoneal fluid exchange.

• ✔ Experienced toxicology team;
• ✔ Collaborative approach from study design to optimization;
• ✔ On-site bioanalytical analysis platform for accurate data and timely report.

To make your specific pre-clinical toxicological objectives possible, please feel free to contact us and you will definitely benefit from advanced infusion technologies.

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