Creative Biolabs provides one-stop services to develop germ-free and custom microbiome animal models for your research. We are pleased to prepare and provide animal models upon requests from clients.

Animal models are essential for research and development in many fields of science. Animal models are frequently employed due to the availability of powerful genetic tools and physiological relevance to humans. Human diseases are increasingly linked with an altered or dysbiotic gut microbiota. It is important to find suitable animal models in which to study the interaction of gut microbiota and the host. Much microbiome research has focused on the mouse as a model organism, and the mouse is the primary choice for preclinical proof of concept studies. The study of germ-free mice has helped to define the role that the enteric microbiota plays in shaping the enteric immune system. Recently, researchers have started using other animal models, including zebrafish, piglets, and Drosophila.

Several Methods to Transfer the Gut Microbiome in Mouse Models

Some studies have shown the ability to transfer disease phenotypes from humans to germ-free mice through microbiota transfers. Currently, there are several different ways to transfer the gut microbiome in mouse models of disease. The embryo transfer (ET) method is considered the gold standard for gut microbiome transfer. For facilities where ET is not possible, researchers often use alternative methods such as fecal microbiome transfer (FMT), co-housing (CH), and cross-fostering (CF). Creative Biolabs provides services of animal model construction through these methods based on our clients’ needs.

Our Capabilities

As an innovative CRO platform based on research animal models, Creative Biolabs is proficient at establishing animal models for gut microbiome research. Our one-stop services include microbiota preparation, isolation, and administration to animals. In addition, we offer you complete animal microbiome analysis for better insights into microbial populations and their functions.

Scientists at Creative Biolabs are dedicated to ensuring the most appropriate animal models based on the project to address the needs of clients. If you are interested in our services, please feel free to contact us.

Reference

1. Zhang, C.; et al. Consideration of gut microbiome in murine models of diseases. Microorganisms, 2021, 9(5): 1062.

For Research Use Only | Not For Clinical Use