Antibiotics and probiotics both modify the gut microbiota. Besides, they are both related to obesity, leading to weight loss. Creative Biolabs offers high-quality services for probiotic & antibiotic modification of gut microbiota to facilitate your specific microbe research needs.

Gut Microbiota & Human Health

The gut microbiota plays an important role in human health and disease. Healthy gut microbiota has many important roles in maintaining the health of the host.

• Prevent the colonization of pathogenic and potentially pathogenic microbial populations, such as Clostridium difficile.
• Develop the host immune system and contribute to the absorption and synthesis of certain vitamins, ions and dietary carbohydrates.
• Associated with important trophic effects such as intestinal epithelial cell regeneration and maintenance of the intestinal mucosal integrity.

Intestinal dysbiosis is defined as a state of imbalance in the population of beneficial to pathogenic bacteria in the intestine. Many factors can disturb or alter the normal healthy intestinal microbiota, including drug use, antibiotic use, drug use, microbial/parasitic infection, immunosuppression, stress, unbalanced diet, lack of exercise, birth by cesarean section and other factors.

Probiotic & Antibiotic

• Probiotic
  Probiotics are live microorganisms that have a health benefits for the host.
• Manipulate gut microbiota, and exert both anti-cancerous and anti-mutagenic activities.
• Protect the intestinal mucosa barrier in colorectal cancer after surgical procedures.
• Prevent infections with colorectal cancer in the postoperative period.
• Antibiotic
  Antibiotic is the most important type of antibacterial agent for fighting bacterial infections, which may either kill or inhibit the growth of bacteria.
• Eradicate Fusobacterium colonization, and reduce colorectal cancer (CRC) proliferation n mice bearing CRC xenograft.
• Reduce bacterial load in tumor and inhibits tumor invasion in mice with or without neutrophil depletion.
• Elicit antitumor immune response and suppresses tumor growth in metastatic mouse models.

Probiotic & Antibiotic Modification of Gut Microbiota

Probiotic and antibiotic modification can both alter the gut microbiota (shown in Fig.1). However, the antibiotic effects are unpredictable due to the complexity of bacterial communities. This might be related to two reasons: 1) direct antibacterial effects on the bacterial populations or to indirect effects. 2) the growth of antibiotic-resistant bacteria that secrete bacteriocins that kill other bacteria irrespective of antibiotic susceptibility or even the bacterial population resistant to the antibiotic used. Moreover, oral antibiotic administration may lead to dysbiosis, with a commonly associated symptom of diarrhea.

Fig.1 Modifications of gut microbiota by antibiotics and probiotics. (Angelakis, 2013)
A) Normal gut microbiota. B) Gut microbiota after probiotic modification. C) Gut microbiota after antibiotic modification.

The combination of probiotics and antibiotics has shown potential in altering the intestinal microbiota to promote health. Recently, studies have demonstrated the success of the coadministration of probiotics with antibiotics in bacterial infections, including C. difficile nosocomial infections and Helicobacter pylori infections. Furthermore, the coadministration of probiotics with antibiotics may also allow for improved patient compliance.

Creative Biolabs provides one-stop services for probiotic & antibiotic modification of gut microbiota to meet all the needs of our customers. If you are interested in our Gut Microbiota Engineering Service, please feel free to contact us.

References

1. Floch, M. H.; et al. Modification of the gut microbiota to promote human health. Clinical Insights: Probiotics, Prebiotics and Gut Health. 2014, 15-34.
2. Angelakis, E.; et al. Related actions of probiotics and antibiotics on gut microbiota and weight modification. Lancet Infect Dis. 2013, 13(10): 889-99.

For Research Use Only | Not For Clinical Use