Why Do Tumor Metabolic Microenvironment Assessment

The metabolic activity of tumor cells is essential to maintain tumor growth and malignancy. Different metabolic processes and alterations in metabolite levels in the tumor microenvironment affect not only the behavior of cancer, but also the efficacy of cancer-specific metabolic drugs. Therefore, the quantitative assessment of metabolic flux and changes in tumors is of great significance for understanding the metabolic characteristics of cancer cells involved in tumor proliferation and invasion.

Hypoxia and pH in Tumor Metabolic Microenvironment

In solid tumors, due to the rapid growth of tumor tissue, but the internal vascular system of the tissue is incomplete, these will lead to insufficient oxygen supply in the tumor tissue, and the tumor microenvironment presents the characteristics of overall hypoxia. Due to the insufficient oxygen supply, tumor cells can only metabolize energy through anaerobic digestion, which will cause the accumulation of lactate, and at the same time, the ion exchange proteins on the tumor cell membrane are also continuously transporting H⁺ from inside the cell to the outside of the cell, avoiding self-acidosis. These cellular responses ultimately lead to varying degrees of pH reduction in the tumor microenvironment, and the overall environment is acidic. Therefore, reliable detection and dynamic visualization of the hypoxic status and pH of tumor cells can inform cancer prognosis and treatment.

WHY US

Creative Biolabs enables rapid and quantitative analysis and evaluation of the tumor metabolic microenvironment through a comprehensive technology platform and advanced analysis systems, which will accelerate the development and validation of predictive characteristics and prognostic biomarkers for tumor immunology applications.

Our Service

You can click on the tumor metabolic microenvironment assessment service you are interested in to learn more:

Hypoxia Detection Service under Tumor Metabolic Microenvironment

• The hypoxic state of tumors is difficult to determine due to differences in oxygen content between tissues, differences in tumor size and measurement methods.
• Creative Biolabs offers you a variety of methods to detect hypoxic status in tumor cells to accelerate your tumor metabolism research.

pH Detection Service under Tumor Metabolic Microenvironment

• pH is a commonly used parameter in TME studies. The success of targeting the pH of the tumor microenvironment depends in part on the accurate detection of the pH of the tumor microenvironment, and the methods now used include PET radiotracer, MR spectroscopy, MRI, and other techniques.
• Relying on advanced instrumentation and professional staffing, Creative Biolabs provides a series of detection methods that target the pH of the tumor microenvironment, providing a strong basis for your tumor metabolism research.

Effect of Abnormal Hypoxia and pH on Tumors

• Promote the growth and metastasis of tumors
• Increase drug resistance in tumors
• Damage to cellular genomes
• Activate DNA damage checkpoints ATM and ATR (Phosphatidylinositol 3-kinase-like protein kinase (PIKK) family)

If you are interested in our tumor metabolic microenvironment assays, please contact us now. Creative Biolabs' experts in the field are always available to help you solve your problems and come up with professional solutions.

Reference

1. Li, Fuming, and M Celeste Simon. "Cancer cells don't live alone: Metabolic communication within tumor microenvironments." Developmental cell. (2020): 183-195.

For Research Use Only | Not For Clinical Use