As experts in the field of tumor metabolism, Creative Biolabs provides a wide range of tumor metabolic characterization services, including metabolic pathway analysis, multi-omics platform, cellular metabolism assays, subcellular metabolic analysis, and metabolic microenvironment analysis. In this module, we launch our featured Tumor Metabolic Microenvironment Analysis Services.

Tumor Metabolic Microenvironment

Altering cellular metabolism brings new hope for cancer treatment. The tumor microenvironment is composed of different cell populations and is often characterized by nutrient competition, low pH, limited oxygen, and metabolite accumulation. The demand for bioenergy from rapidly proliferating cancer cells causes cancer cells and immune cells to compete for nutrients needed for anti-tumor defenses. In this case, the tumor itself undergoes metabolic changes, producing an inhibitory immune microenvironment, which in turn inhibits the anti-tumor immune response. And it is worth noting that immune cells that migrate to TME also undergo metabolic changes, develop an immunosuppressive or tolerant phenotype, and promote a metabolism that is more dependent on oxidative phosphorylation and fatty acid oxidation to meet energy requirements. Ultimately, the effectiveness of the anti-tumor immune response of immune cells is disrupted.

Fig.1 Tumor microenvironment and associated immune cell metabolism.¹

Our Service

For the analysis and detection of the tumor metabolic microenvironment, Creative Biolabs offers the following two different services. Please click on the content you are interested in for more information.

Tumor Metabolic Microenvironment Assessment Services

• In solid tumors, due to the rapid growth of tumor tissue, but the internal vascular system of the tissue is incomplete, these will lead to insufficient oxygen supply in the tumor tissue, the tumor microenvironment is hypoxic, and the cellular environment is acidic.
• Creative Biolabs enables rapid quantitative analysis and assessment of hypoxic status and pH of the tumor metabolic microenvironment, which will accelerate the development and validation of predictive characteristics and prognostic biomarkers for immuno-oncology applications.

Single Cell Metabolic Analysis Services for Tumor Microenvironment Heterogeneity Research

• Single-cell metabolic profiling is a tool to study tumor cell metabolites at the single-cell level with extremely high resolution, providing a more objective way to understand tumors in depth.
• Creative Biolabs offers a variety of services including single cell metabolomics, spatial metabolomics, mass cytometry by iime-of-flight (CyTOF), metabolic cytometry, and in situ dehydrogenase activity assay to help accelerate your tumor metabolism program.

Tumor Metabolic Microenvironment Analysis Process

Fig.2 Research ideas on tumor glucose metabolism and immune microenvironment. (Creative Biolabs)

Why Choose Creative Biolabs

Creative Biolabs has developed a unique service system to meet your analytical needs through years of research and discovery of knowledge and research related to tumor metabolism.

If you are interested in one of our above tumor metabolic microenvironment analysis services, please contact us now! Alternatively, you can consult us for customized tumor metabolism-related services and testing.

Reference

1. Bader, J.E.; et al. "Targeting metabolism to improve the tumor microenvironment for cancer immunotherapy." Molecular cell. (2020): 1019-1033.

For Research Use Only | Not For Clinical Use