Venom peptides need to be stable enough to degrade or digest at ambient temperatures. By optimizing and modifying different sites of peptides, the stability of venom peptides can be improved. In addition, the use of venom peptides for drug delivery is also one of the current research hotspots. Creative Biolabs provides a variety of venom peptide optimization services, providing you with professional technical support and reliable solutions from different research directions.

Our Optimization of Venom Peptide Service

• General Venom Peptide Modification

The Stability of venom peptides can often be achieved by post-translational modifications (PTMs) or disulfide bonds. In the production process of venom peptides, the introduction of specific modifications through technical means can improve their stability and also provide their bioavailability. Creative Biolabs offers a range of peptide modification services at our Venom Peptides Synthesis unit to meet your needs.

Fig.1 The sequences of some known venom peptides.¹

• Optimization of Venom Peptide Delivery

Venom peptides are less orally available due to their large size and hydrophilic properties. Therefore, improving the drug delivery mode of venom peptide is also an important way to develop it.

• Lipophilic modification

The bioavailability of venom peptides can be improved by altering the structure of the venom peptide and thus altering the permeability.

• Nanoformulation

Venom peptides have been shown to treat many diseases such as cancer, pain, cardiovascular disease, etc. By using the method of nanopreparation, the toxicity and targeted delivery of the venom peptide conjugated to it can be reduced.

Fig.2 Application of nanoparticle-formulated venom peptides.²

• Blood-brain barrier (BBB)

In addition to protecting the brain from toxic substances, the barrier also prevents the entry of many potential drugs for neurological disorders and tumors. The optimized venom peptide can be used to deliver drugs across the blood-brain barrier.

Fig.3 Venom peptides are one of the sources used for BBB shuttle.³

• High-throughput expression of Venom Peptide

Disulfide reticuloid peptide in animal venom has the characteristics of high specificity and low immunogenicity, and can target a variety of membrane receptors. High-throughput expression and generation of disulfide-bonded peptide libraries by E. coli.

Fig.4 Schematic diagram of high-throughput production of venom peptides in Escherichia coli.⁴

Creative Biolabs has accumulated a wealth of knowledge and experience in peptide structure modification for many years, and we have a professional team and advanced equipment to help you with your venom peptide project. If you have any questions about your development and research of venom peptides, you can contact us now.

References

1. Shin, Min Kyoung.; et al. "In silico identification of novel antimicrobial peptides from the venom gland transcriptome of the spider Argiope bruennichi (Scopoli, 1772)." Frontiers in microbiology. (2023) 14 1249175.
2. Joglekar, A.V.; et al, "Therapeutic potential of venom peptides: insights in the nanoparticle-mediated venom formulations." Futur J Pharm Sci. (2022)
3. Sánchez-Navarro, Macarena, and Ernest Giralt. "Peptide shuttles for blood-brain barrier drug delivery." Pharmaceutics. (2022) 14,9 1874.
4. Turchetto, J.; et al. "High-throughput expression of animal venom toxins in Escherichia coli to generate a large library of oxidized disulphide-reticulated peptides for drug discovery." Microbial cell factories. (2017).

For Research Use Only | Not For Clinical Use