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HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
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HighlightsIt has been proven in nature that alligators have a far stronger immune system than humans. Alligators often fight predators in treacherous environments, resulting in severe injuries. However, they recover quickly, and their wounds do not become infected. Beginning in 1998, the scientific community began to pay attention to alligators' superb immune systems. The results showed that alligators' serum may contain powerful anti-biotic substances that can be used to fight bacterial and viral infections. Based on our rich field experience and advanced antibody preparation platform, Creative Biolabs provides comprehensive antibody discovery services to support monoclonal alligator antibody production.
Most alligators inhabit sandy swamps and rivers. In general, living in such unclean environments makes an injury highly susceptible to wound infection, which can lead to severe scurvy and fatal injuries. But alligators, which often fight with predators, often recover quickly from wounds, no matter how gruesome they are. This natural phenomenon has attracted the attention of countless people, scientists explored the mystery of this superpower of alligators to resist bacterial and viral infections.
Studies showed that certain proteins contained in alligators' serum were able to kill bacteria that were resistant to penicillin, such as Staphylococcus aureus. In addition, alligators' serum contains potent bactericidal peptides that effectively kill pathogens. Some of these proteins, in particular, are even more efficient than man-made antibiotics. Many antibiotics are helpless against methicillin-resistant Staphylococcus aureus, but alligators' serum kills this bacterium immediately. Alligators' serum is not only a killer of bacteria, but it also kills viruses. A study has shown that alligator serum kills much more HIV than human serum does. The way alligators deal with HIV is different from the way the human immune system attacks the virus head-on as soon as it invades; the antibodies of the alligators' immune system attach to the virus, disintegrate it after splitting it, and kill it. In addition to HIV, alligators' serum has significant antiviral activity against West Nile virus and herpes simplex virus type I, among others.
The roots of the alligators' superb immunity are also genetic. For example, in the Yangtse crocodile, 43 families of immune-related genes have expanded, leaving other reptiles in the dust. One study showed that IgM1 and IgM2 in alligator serum are present as multimers, which means that IgM category switching may also play an important role in humoral immunity. Class switching is the phenomenon in which Ig classes are expressed on the membrane and secreted by B cells after antigen activation switch from IgM to other classes or subclasses of Ig, such as IgG, IgA, and IgE, during the immune response.
All of this evidence suggests that alligator blood and alligator genes have an important role to play in the treatment of human diseases. The in-depth study of alligator serum and alligator genes could lead to the development of monoclonal alligator antibodies for more effective diagnosis and treatment of infectious diseases. Phage display technology is an important tool for the preparation of monoclonal alligator antibodies. Rapid access to monoclonal alligator antibodies can be realized by phage display library construction. The immune antibody library can even realize the obtaining of the target antibody in a smaller library capacity.
Creative Biolabs has a wealth of knowledge and experience in monoclonal antibody discovery. We would be happy to share with you our knowledge and experience related to monoclonal alligator antibody discovery.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
