Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsMonoclonal antibodies are biological macromolecules with a wide range of applications. They occupy an important position in the fields of medical diagnosis, disease treatment, and targeted drug delivery. Compared with polyclonal antibodies, monoclonal antibodies are more suitable for detecting single antigens. In different application environments, monoclonal antibodies and polyclonal antibodies have their own scope of applications. Based on our rich field experience and advanced monoclonal donkey antibody preparation platform, Creative Biolabs provides comprehensive antibody discovery services to support monoclonal donkey antibody production.
Monoclonal antibodies are antibodies produced by a single clone of B cells and can bind to specific antigens. Monoclonal antibodies are usually more specific and have higher affinity than polyclonal antibodies, and therefore have been widely used in biomedical research and therapy. Donkeys are commonly used as experimental animals, and their immune systems can produce a variety of antibodies. By immunizing donkeys with antigens, polyclonal antibodies can be obtained. However, polyclonal antibodies usually have lower specificity and affinity and are therefore not suitable for some applications. In contrast, monoclonal donkey antibodies have high specificity and affinity and may be a better choice in some cases.
A study showed that anti-distemper virus IgG prepared from donkey serum had significant antiviral effects against canine distemper virus (CDV). In addition, donkey, as a member of large mammals from a wide range of sources, can produce more antibody products to treat canine infectious diseases. This can greatly reduce the cost of treatment and make this treatment more popular. In passive immunotherapy using antibodies from heterologous animals, it is necessary to consider the immune rejection of heterologous proteins by the receptor. The results of this study showed that although there were no strong toxic side effects of treating canine distemper disease with donkey-derived IgG, there were some adverse reactions. The authors hypothesized that these reactions may be related to IgG purity and immune rejection of heterologous IgG by the receptor. To solve these problems, the preparation conditions should be optimized to improve the quality of IgG. In addition, the IgG should be modified. An effective method commonly used today is to treat IgG with papain to cut off the Fc fragment of IgG and prepare the Fab fragment of IgG, thus reducing the antigenicity of IgG. In order to improve the therapeutic effect of donkey-derived anti-CDV IgG, IgG can be chemically modified. Chemical modification cross-links certain cytokines (or chemokines) to stimulate or recruit immune cells to directly kill infected CDV.
Antibody preparation by phage display technology is a commonly used technique for antibody preparation. The phage display library construction can mimic the process of natural antibody library formation without the need for a tedious and time-consuming immunization process. This greatly improves the efficiency of monoclonal antibody preparation and provides a powerful screening capability against arbitrary antigens or even unknown antigens. Generally, commonly used antibodies can be obtained from natural or semi-synthetic antibody libraries. This is the important and most frequently used method to obtain antibodies for most phage display techniques. However, some experiments and studies have higher requirements for antibodies. In many cases where antibody specificity and affinity are required, immune antibody libraries can be constructed. Immune antibody libraries can be enriched by antigen-specific antibodies, and a large percentage of the libraries encode functional antibodies that recognize specific immunogens.
Creative Biolabs has a wealth of knowledge and experience in monoclonal antibody discovery. We would be happy to share with you our knowledge and experience related to monoclonal donkey antibody discovery.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
