Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsCompared to rodents, monkeys are large animals and have a similar genetic background to humans. Studies have shown that non-human primates are closest to humans in terms of kinship. It shares 75–98.5% of its genetic material with humans. This characteristic makes laboratory monkeys important in preclinical new drug development and the ideal animal to be closest to humans in experiments. It is also for this reason that monoclonal monkey antibodies have higher homology with human antibodies in antibody development and research. Based on our rich field experience and advanced antibody preparation platform, Creative Biolabs provides comprehensive antibody discovery services to support monoclonal monkey antibody production.
Fig 1. Antibody
Monoclonal antibodies are produced by B cells. It is able to specifically target immunoglobulins to antigens. Monoclonal antibody is not only an essential tool in biochemistry, molecular biology, and medical research, but it has also demonstrated amazing performance in clinical therapeutic applications, with good therapeutic effects on refractory tumors.
Initially, the preparation of monoclonal antibodies was mainly based on hybridoma technology in mice. However, murine monoclonal antibodies are highly immunogenic and can cause human anti-mouse antibody reactions in clinical applications, leading to a shortening of the half-life of the murine antibody, which in turn leads to a weakening of the therapeutic effect. With the development of technology, people have been able to prepare the desired antibodies on more animals, and it has even been possible to prepare fully human antibodies. However, animal-derived antibodies remain an essential and important tool in preclinical studies. Since fully human antibodies are generally hosted in non-mammalian cells, such as E. coli, and have not been produced by expression in mammalian cells or in vivo, they may have some activity deficiencies and often need to undergo subsequent modifications.
Laboratory animals are the main experimental subjects for the preclinical evaluation of drugs. Monkeys, as non-human primates, are an even more important species in preclinical studies. Non-human primates are closest to humans in terms of kinship. Antibodies, as a biomolecular drug, may produce a strong stimulus upon entry into the organism, leading to the production of specific antibodies and sensitized lymphocytes. The production of anti-drug antibodies may cause allergic reactions, immunosuppression, autoimmune reactions, and other adverse reactions in the body. The severity of these adverse reactions can range from mild to life-threatening. Monoclonal monkey antibodies have higher homology with monoclonal human antibodies due to the evolutionary similarity of the species. Therefore, immunological and pharmacological studies using monkeys as test subjects are more reliable than those using other mammals. At the same time, the anti-drug antibodies produced by monkeys against certain drugs can often approximate the response to the same drug in humans. Monoclonal monkey antibodies have an irreplaceable role in antibody research and development. However, the preparation of monoclonal monkey antibodies is not an easy task. The acquisition and breeding of monkeys alone require high conditions and costs. Therefore, the preparation of monoclonal monkey antibodies often has high technical barriers.
Monkey-derived immune antibody libraries are excellent tools for studying the humoral immunity of an organism to an antigen. Enrichment of antigen-specific antibodies by phage display library construction. Antibody libraries have a higher rate of encoding functional antibodies capable of recognizing specific immunogens and can be screened for functional antibodies and their genes against immunogens from antibody libraries with smaller library capacities. This approach can produce more or even better antibodies compared to the hybridoma route. Moreover, antibodies generated based on immunize antibody libraries may have higher affinity than those obtained by conventional techniques.
Creative Biolabs has a wealth of knowledge and experience in monoclonal antibody discovery. We would be happy to share with you our knowledge and experience related to monoclonal monkey antibody discovery.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
