Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsThe preparation of monoclonal antibodies is gradually progressing with technological development. With their high specificity and single biological function, monoclonal antibodies are more and more widely used in the fields of biological research and medicine. Monoclonal rat antibodies have many unique advantages among monoclonal antibodies. Rats have genetic similarities closer to humans, which means that monoclonal rat antibodies can recognize a wide range of antigens and can produce IgA, IgD, IgE, IgG, and IgM antibody isotypes. Despite the many advantages of monoclonal rat antibodies, there are no mature tumor cell lines for fusion in the rat experimental system, thus increasing the difficulty in monoclonal rat antibody preparation. Based on our rich field experience and advanced antibody preparation platform, Creative Biolabs provides comprehensive antibody discovery services to support monoclonal rat antibody production.
Monoclonal antibodies are highly homogeneous antibodies produced by a single B-cell clone that target only a specific antigenic epitope. Monoclonal antibodies have many advantages. In the case of monoclonal antibodies prepared using hybridoma technology, the hybridoma can be "perpetuated" in vitro and passed on. As long as there is no genetic mutation in the cell line, highly specific and homogeneous antibodies can be produced continuously. Monoclonal antibodies are characterized by high specificity, high targeting, high purity, good homogeneity, and a single biological function, which makes them useful in the treatment of diseases.
At present, monoclonal antibodies are widely used in medical diagnosis and clinical treatment. Monoclonal antibodies have the advantages of high specificity and homogeneity, which can be used as diagnostic reagents in medical laboratories and then used in enzyme-linked immunosorbent assay (ELISA), radioimmunoassay (RIA), immunohistochemistry (IHC), and flow cytometry (FCE) techniques. In addition, monoclonal antibodies can be used in the treatment of tumors, rheumatoid arthritis, viral infections, and other diseases. During tumor treatment, monoclonal antibodies can play a guiding role, carrying drugs or radiotherapy substances to the target organ and killing the target cells directly. In addition, by linking radioactive markers with monoclonal antibodies and injecting them into the patient's body, radioimmunoimaging can be carried out to assist in the diagnosis of tumors. In addition, monoclonal antibodies have a broader role in protein purification and other areas.
Monoclonal rat antibodies are highly specific antibodies prepared by immunizing rats and screening positive monoclones by fusing their activated B cells with tumor cells. Monoclonal rat antibodies have many advantages over monoclonal mouse antibodies and rabbit polyclonal antibodies. For example, they are perfectly suited to mouse antigens and generally do not produce background cross-reactivity when detecting antigens of mouse origin. At the same time, it solves the problem that antibodies against mouse proteins are difficult to produce in mice themselves. What's more, rat monoclonal antibodies have high similarity to human Fc. It can detect poorly immunogenic compounds and low molecular weight small molecules and can be used in multilabeling experiments. The rat immune antibody library based on phage display technology has many advantages in screening antibodies. Due to the selective pressure of immunization, the abundance of specific antibodies against the corresponding immunogens in the immune antibody library is much higher than that of other non-specific antibodies, and some of these specific antibodies have gone through the affinity maturation process of the immune system so that high-affinity and high-specificity antibodies can be screened from such immune antibody libraries. However, phage display library construction is the focus of this technology. Nucleic acid fragments of different sequences used for library construction are obtained by synthetic methods, cDNA methods, and random hydrolysis of DNA by DNaseI. Phage display systems commonly used for library construction are single-stranded filamentous phage display systems, λ phage display systems, T4 phage display systems, and T7 phage display systems.
Creative Biolabs has a wealth of knowledge and experience in monoclonal antibody discovery. We would be happy to share with you our knowledge and experience related to monoclonal rat antibody discovery.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
