Baboon Plasma (NHP-BP013)

The article explores the thrombin generation profile in Chacma baboons (Papio ursinus), commonly used in preclinical models for hemostatic diseases like acquired thrombotic thrombocytopenic purpura and bacterial sepsis-induced disseminated intravascular coagulation.

This study assesses thrombin generation parameters such as lag times, peak heights, times-to-peak, velocity indexes, and Endogenous Thrombin Potentials (ETPs) in 40 adult Chacma baboons, comparing them with normal human plasma.

The study found that while lag times of all baboons fell within the human reference interval, most had times-to-peak and velocity indexes significantly different from humans. Notably, 97.5% of the baboons had an ETP above the human reference interval, indicating greater overall thrombin generation. The study also observed sex-related differences; male baboons had less potent thrombin generation than females, with longer lag times and lower peak thrombin concentrations and ETPs.

This significant finding implies that Chacma baboons, particularly females, have greater overall endogenous thrombin generation potential than humans. This difference is crucial for designing future baboon model experiments and evaluating novel therapies involving the hemostatic system.

Fig. 1 Baboon thrombin generation curve ranges, compared with a selection of normal human plasmas, ran for 90 min. The graph depicts the mean thrombin concentrations of all 40 baboons and 13 normal human plasmas, ± 1SD at the various indicated timepoints. The lower line represents the mean—1SD, and the upper line represents the mean + 1SD. nM nanomolar.

Fig. 2 Comparison of Papio ursinus thrombin generation parameters of all baboons (n = 40), and all subgroups, with corresponding human data (n = 44).

Reference

1. J. Joubert .,et al. "The thrombin generation capability of the Chacma baboon (Papio ursinus): implications for haemostatic disease models" Nature. Scientific Reports.(2023) 13:22968