NHP Based In Vitro Pharmacokinetics Study Service

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In the early stage of drug discovery and development, it's essential to understand the key pharmacokinetics (PK) information including absorption, distribution, metabolism, and excretion (ADME) and drug-drug interaction (DDI) properties of candidate compounds. In vitro PK studies are not only the regulatory agency's recommendations for drug development programs but also the basis for a series of subsequent studies. At Creative Biolabs, our dedicated team provides full support for your non-human primate (NHP) based in vitro PK studies flexibly and efficiently.

What Services We Can Provide

At Creative Biolabs, our in vitro PK services are launched based on collecting customer needs and suggestions and can match your R&D plan dynamically. Whether you need the help of a single piece of PK research or want to commission the entire PK project as a package, we can design the most suitable solution according to the project details you provided.

  • Drug Distribution

The level of the free drug in the plasma is closely related to its exact efficacy. Thus, the rate of drug binding with plasma protein can help researchers obtain predictive information about the volume of distribution, half-life, organ distribution, and clearance of drugs. Creative Biolabs offers NHP-based drug distribution-related research including plasma protein binding (PPB), red blood cell (RBC) partitioning, and plasma stability.

  • Drug Metabolism

Metabolic stability is a key factor that may lead to unexpected side effects due to slow clearance. Creative Biolabs utilizes NHP-derived microsomes, S9, and hepatocytes as in vitro models to evaluate the metabolic stability of your candidates, supporting you in achieving a balance between metabolic stability and efficacy in the drug discovery stage. If you want to analyze drug metabolic pathways and metabolites, we also have the corresponding solutions.

  • Drug-Drug Interaction

Creative Biolabs offers a large range of NHP-based drug interaction assay services to reduce the risk of your candidate as a DDI victim or perpetrator.

Types of DDI services provided by Creative Biolabs

DDI studies Research purpose NHP-derived enzyme types
Enzyme Induction Evaluate the induction potential of drugs on drug-metabolizing enzymes CYP 3A4, CYP 3A5, CYP 1A2, CYP2B6, CYP 2C8, CYP 2C9, CYP 2C19.
Enzyme Inhibition Evaluate the inhibition potential of drugs on drug-metabolizing enzymes CYP: CYP 3A4, CYP 3A5, CYP 1A2, CYP 2B6, CYP 2C8, CYP 2C9, CYP 2C19, CYP 2D6, CYP2A6, CYP2E1. UGT: UGT1A1, UGT 1A3, UGT 1A4, UGT 1A6, UGT 1A9, UGT 2B7, UGT 2B15, UGT 2B17.
Drug metabolizing enzyme (DME) phenotyping Find the main drug-metabolizing enzymes involved in the primary metabolism of a drug candidate. CYP 1A1, CYP 1A2, CYP 2A6, CYP 2B6, CYP 2C8, CYP 2C9, CYP 2C19, CYP 2D6, CYP 2E1, CYP 3A4, CYP 3A5.

Why Partner with Creative Biolabs

Creative Biolabs values the project of each client and will impose strict quality control in the overall process of project design and implementation. We have confidence that our high-quality services will make your project a success. Don't hesitate to contact us if you have any needs.

Fig.1 The strengths of our in vitro pharmacokinetics services (Creative Biolabs Original)

FAQ

  1. How do NHP in vitro studies aid in the development of new drugs?
    NHP in vitro studies play a critical role in the early stages of drug development. They provide valuable insights into the metabolism, toxicity, and efficacy of new compounds. This information is essential for determining appropriate dosing and potential side effects, thereby helping to streamline the drug development process and reduce the risk of late-stage failures in clinical trials.

Customer Review

  • Dr. Jane Wilson, Pharmacokinetics Researcher.
    I recently collaborated with Creative Biolabs for an in vitro pharmacokinetics study using NHP models. The team's expertise in drug distribution, metabolism, and drug-drug interaction studies provided comprehensive insights. They used NHP-derived models like microsomes and hepatocytes efficiently, which significantly contributed to my project's success. Their service was flexible and tailored to my research needs, demonstrating high-quality work and strict quality control throughout the project.

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