NHP Based Pharmacology and Pharmacodynamics Service

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Following closely the industrial development trend, Creative Biolabs offers comprehensive non-human primate (NHP) based pharmacology and pharmacodynamics (PD) services to accelerate global researchers' projects. Our dedicated team has decades of experience in drug development. Whether you desire an integrated preclinical service or a stand-alone pharmacology and pharmacodynamics research, we have the confidence to get your research to succeed with our comprehensive NHP platform.

NHP Based In Vitro Pharmacology Service

Creative Biolabs has established a mature NHP-based in vitro pharmacology platform and can provide our global customers with enough space to choose the type of service they desire. We have optimized the protocol for every research category and will ensure the precision and reliability of data for your project.

Types of in vitro pharmacology services

Research Type Purpose Description
  • Immunostimulatory Assays
  • Metabolism Enzymes Inhibition
  • Transporters Inhibition
Evaluation of immunostimulatory effect Analyze the release course of relevant cytokines through the immunoassays based on monkey whole blood and PBMCs.
Assessment of the effect on drug metabolism Utilize primate liver microsomes or primary hepatocytes to test the potential inhibitory effect of drugs on CYP 450 enzymes.
Explore the effect on drug transporters Exploit primary monkey cells to test the potential inhibitory effect of drugs on ABC drug transporters.

NHP Based In Vivo Pharmacodynamics (PD) Service

At Creative Biolabs, we are deeply aware of the significance of in vivo PD research for bridging your preclinical studies and clinical applications. Based on multiple species of NHPs and years of experience, we have put efforts into establishing the NHP-based in vivo PD platform. To date, we have launched a series of service types to help you conduct the PD study based on biomarkers related to genes, small molecules, and proteins through our validated non-human primate models. You can also obtain high-quality cellular, histologic, and immunologic phenotyping analysis data from our extensive services.

Types of NHP-based in vivo PD service

Research Type Purpose Description
  • Concurrent PD
  • Specialized PD
  • Exploratory PD
  • Confirmatory PD
  • Tissue-specific efficacy
Assessment of systemic biomarker level during pharmacokinetic study The biomarker level in the systemic circulation is measured during the PK study.
Evaluation of systemic biomarker level through a specially designed experiment The biomarker level in the systemic circulation is measured through a well-designed experiment.
Explore the systemic level of biomarkers affecting efficacy and safety Efficacy and biomarker levels are measured by multiplex assays during the PK study.
Study the tissue specificity or biomarker levels through a confirmatory experimental design The biomarker levels in the different tissues are measured during the clinical pharmacology or toxicology study.
Analyze the tissue distribution of biomarkers during pharmacokinetic study Specific tissues and fluids are obtained by biosampling, biopsy, or microdialysis to measure the biomarker level during the PK study.

Why Partner with Creative Biolabs

Creative Biolabs has been adhering to technology innovation and the improvement of service quality since its inception, which has won numerous positive comments from global clients. With a professional scientific team, we're confident to bring you a smooth drug development experience.

Fig.1 The strengths of Creative Biolabs in pharmacology and pharmacodynamics services (Creative Biolabs Original)

In addition to pharmacology and pharmacodynamics services, Creative Biolabs also offers other NHP-based research services for your preclinical program. Welcome to contact us for more service details.

FAQ

  1. How are side effects managed in NHP pharmacology studies?
    Understanding and managing side effects is a crucial aspect of NHP pharmacology and pharmacodynamics. Most drugs can cause unwanted side effects in addition to their intended action, even when administered at recommended doses. This is particularly important in NHP studies as these models are often used to predict human responses. Researchers must have a deep understanding of pharmacokinetics and pharmacodynamics to anticipate and mitigate adverse drug reactions. This involves identifying medicines and patient groups at increased risk, understanding the mode of action of drugs, and applying this knowledge to prevent harmful interactions and side effects.
  2. What are common compliance issues in pharmaceutical research involving NHP?
    Compliance with regulatory standards is a significant concern in pharmaceutical research, including studies involving NHP. Common issues include inadequately documented Standard Operating Procedures (SOPs), insufficient records of cGMP (current Good Manufacturing Practice) training, and failures in laboratory controls. These issues can lead to noncompliance with regulatory requirements, affecting the reliability and safety of pharmaceutical products. Ensuring scientifically sound lab controls, proper maintenance of equipment, and effective SOPs are essential for compliance and quality assurance in pharmaceutical research.

Customer Review

  • Dr. Elizabeth Grant, Senior Pharmacologist.
    We approached Creative Biolabs for their expertise in NHP Based Pharmacology, focusing on CNS drug safety. Their approach, employing NHP models, provided us with critical insights into the behavioral and cognitive effects of our CNS drug candidates. The similarities observed between NHP and human responses greatly enhanced our confidence in the translational value of our research. This collaboration not only advanced our understanding of the drug's safety profile but also reinforced our commitment to developing safer CNS therapeutics.

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