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Creative Biolabs: Expert in NHP-based biomarker research.

Creative Biolabs is a reputable NHP-related service provider that has expertise in preclinical drug discovery, especially in biomarker discovery and validation. We possess core technologies to address critical technical challenges, such as throughput, sensitivity, reliability, and usability, and focus on offering competitive biomarker solutions for research organizations or groups from multiple continents around the world.

Why Biomarkers are Important

Biomarkers are key assessment indicators to monitor the biological process of an organism and play an essential role in exploring action mechanisms and pharmacodynamic aspects of drugs in the new drug development pipeline. Besides, when it comes to clinical applications, biomarkers are also used as a convenient tool for diagnosis and prevention of the disease. Thus, starting early to lay out your biomarker research route can help improve the efficiency and success rate of drug commercialization.

What We Can Provide

Biomarker research will be involved in the whole process of pharmacology and pharmacodynamics analysis, pharmacokinetics evaluation, and safety assessment. Creative Biolabs provides a suite of biomarker discovery, verification, and validation research services on the gene, protein, and cell levels for our global clients. Specifically, we have multi-omics solutions covering genomics, transcriptomics, proteomics, lipidomics, and metabolomics for you to choose. Even for some research, you don't have to deliver a sample and only tell us your specific needs, we can conduct the research you are interested in by utilizing ready-made or freshly prepared samples from our NHP disease models.

The capabilities of our biomarker discovery and validation platform

Based on our advanced technique platform, our professional research team with focused expertise will make your project benefit from the biomarker strategy to a great extent.

Why Partner with Creative Biolabs

Creative Biolabs has years of practical experience in all aspects of biomarker research and can offer a unique solution for your project. Our services, both in terms of breadth and depth, are ahead in the industry. If you value research efficiency and data accuracy, choosing Creative Biolabs will be a decision you will never regret. For more details, please contact us in time to talk with our specialists.

Published Data

The article focuses on identifying novel biomarkers for acute radiation injury using a multiomics approach in a non-human primate (NHP) model. The study utilized a comprehensive analysis combining metabolomics, proteomics, and lipidomics to develop a reliable biomarker panel. The key result was the identification of a 4-analyte biomarker panel, capable of accurately stratifying irradiated NHPs from non-irradiated ones across all tested doses of gamma rays. This panel, including Serpin family A9, acetylcarnitine, glycerophosphocholine (16:0/22:6), and suberylglycine, showed significant potential for human application following further validation. The study emphasizes the advantages of using NHP models for biomarker discovery due to their closer physiological and immunological resemblance to humans, providing more relevant data for human health applications. The findings are significant for developing minimally invasive assays for radiation exposure assessments and have implications for personalized medicine and public health safety.

Fig. 1. Radiation-induced metabolic response in nonhuman primates (NHPs). Study schema for NHP irradiation and sample collection (A). Pathway analysis showing metabolic perturbations after irradiation in NHPs receiving 8.5 Gy (B). A heat map of most significantly dysregulated metabolites at different doses of radiation in a time-dependent manner (C).

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