BAI1 Polyclonal Antibody (NHP-AB310)

• This product is an antibody that was generated by immunizing rabbit against a peptide located in the N-Terminal domain of BAI1 (Human). It is used only in in vitro assays.

Detailed Product Description

• Introduction: BAI1 is a phosphatidylserine receptor that enhances the engulfment of apoptotic cells, likely to be a potent inhibitor of angiogenesis in brain, and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. BAI1 may function in cell adhesion and signal transduction in the brain. Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. As such, tumors obtain blood supply for their growth, are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one functional p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI1 and BAI3, which have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas. Diseases associated with BAI1 include Glioblastoma.
• Conjugate: None
• Applications: ELISA; IHC

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Bovine; Gibbon; Gorilla; Human; Monkey
• Immunogen: A peptide located in the N-Terminal domain of BAI1 (Human)

Product Property

• Purification: Immunoaffinity Chromatography
• Format: Liquid
• Concentration: 0.7 mg/mL
• Buffer: PBS, 0.1% sodium azide.
• Storage: Short term: 4˚C. Long term: Store at -20˚C.

Target Information

• Clonality: Polyclonal
• Alternative Names: Adhesion G protein-coupled receptor B1; Brain-specific angiogenesis inhibitor 1; FLJ41988; Vasculostatin-120; Vasculostatin-40; Vstat-40; Vstat120; Vstat40
• Entrez Gene ID: 575