- This product is an antibody conjugated with biotin that was generated by immunizing mice against a human adherent peripheral blood cells. It is used only in in vitro assays.
Detailed Product Description
- Introduction: CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily
glycosylated type I transmembrane protein that constitutes the major sialoglycoproteins
on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in
extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains,
and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by activated T
cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium, and some
tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular
antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane
by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and
CD107b on the surface of tumor cell lines has been associated with their enhanced
metastatic potential where they may increase adhesion to extracellular matrix and
endothelium. - Conjugate: Biotin
- Antibody Isotype: IgG1
- Applications: Flow Cytometry; IHC-Fr; WB; IP
Technical Specifications
- Host Species: Mouse
- Species Reactivity: African green Monkey; Human
- Immunogen: Human adherent peripheral blood cells
Product Property
- Format: Liquid
- Buffer: Supplied in PBS/NaN3
- Storage: Store at 4⁰C.
Target Information
- Target: CD107a
- Clone: B4C3
- Clonality: Monoclonal
- Alternative Names: CD107 antigen-like family member A; CD107a; LAMP-1; lysosomal-associated membrane protein 1; Lysosome-associated membrane glycoprotein 1; lysosome-associated membrane protein 1
- Entrez Gene ID: 3916
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