CD79a Recombinant Antibody (R4LA) (NHP-AB502)

• This product is a recombinant antibody recognizing CD79a. It is used only in in vitro assays.

Detailed Product Description

• Introduction: CD79a is a disulphide-linked heterodimer that includes B29 (CD79b) polypeptide. CD79a is a B lymphocyte antigen receptor with an antigen-specific surface component Ig (immunoglobulin) that associates with Ig-alpha and Ig-beta, necessary elements for the expression and function of the B-cell antigen receptor. CD79a first appears at pre-B cell stage and persists until the plasma cell stage where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B cell type, in B cell lines, B cell lymphomas, and in some myelomas. It is not present in myeloid or T cell lines.
• Conjugate: None
• Antibody Isotype: IgGk
• Applications: IHC-P; WB

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Bovine; Human; Monkey; Mouse; Pig; Rat
• Immunogen: Amino acids 202-216 (GTYQDVGSLNIADVQ)

Product Property

• Purification: Protein A Affinity Chromatography
• Format: Liquid
• Concentration: 0.2 mg/mL
• Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
• Storage: Store at 4⁰C. Avoid freez-thaw cycles.

Target Information

• Clone: R4LA
• Clonality: Monoclonal
• Related Disease: Diseases associated with CD79a include Agammaglobulinemia 3 and Agammaglobulinemia, Non-Bruton type.
• Alternative Names: CD79A, Ig-alpha, IGA; Igalpha; Ly-54; Ly54; MB-1; MB1
• Entrez Gene ID: 973
• Function: Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.