CXCR4 Monoclonal Antibody (I79RO) (NHP-AB207)

• This product is an antibody that is used only in in vitro assays.

Detailed Product Description

• Introduction: CXCR4 (Fusin, LESTR, HUMSTR) is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a co-receptor for X4 HIV-1 entry into CD4+ cells. CXCR4 has been proved to be the co-receptor for HIV-2's binding to CD4 through envelope glycoprotein gp 120 and promotes Env-mediated fusion of the virus. In other cases, CXCR4 can even function as the only receptor for HIV-2's binding to the CD4 host cells. CXCR4 is the receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. CXCR4 acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Also, CXCR4 is involved in hematopoiesis and in cardiac ventricular septum formation, and plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. In the CNS, CXCR4 could mediate hippocampal-neuron survival and is involved in cerebellar development. CXCR4 binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes.
• Conjugate: None
• Antibody Isotype: IgG2a
• Applications: Flow Cytometry; IF; IHC

Technical Specifications

• Host Species: Mouse
• Species Reactivity: Monkey

Product Property

• Purification: Affinity Chromatography
• Format: Liquid
• Concentration: 0.5 mg/mL
• Buffer: PBS, pH 7.2, 0.09% sodium azide. Sourced from tissue culture supernatant.
• Storage: Store at 4⁰C. Avoid freezing.

Target Information

• Target: CXCR4
• Clone: I79RO
• Clonality: Monoclonal
• Alternative Names: C Cmotif chemokine; C X C motif chemokine; C-X-C chemokine receptor type 4; CC motif chemokine; CD antigen CD184; CD184; chemokine (C-X-C) receptor 4; chemokine receptor 4; CXC; CXC motif chemokine; CXC-R4; CXCR-4; Fusin; HUMSTR; LESTR; Leukocyte-derived seven transmembrane domain receptor; leukocyte-expressed seven-transmembrane-domain; PB-CKR; Pre-B-cell-derived chemokine receptor; SDF-1 receptor; Stromal cell-derived factor 1 receptor
• Entrez Gene ID: 7852