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Cynomolgus Monkey Breast Milk (NHP-BF022)

Non-Human Primate (NHP) Breast Milk Products, Cynomolgus Monkey, Breast Milk
Category:Non-Human Primate (NHP) Breast Milk Products
Tag: Cynomolgus Monkey, Breast Milk
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  • In scientific research, the Cynomolgus monkey is often used in neuroscience and disease-related experiments. This available product is collected from Cynomolgus monkeys' mammary glands. The sample is high-quality and offered in a cryopreserved or fresh form. It can be applied to a number of tests and assays, for example, PCR, WB, immunoprecipitation, and immunofluorescent flow cytometry.

Detailed Product Description

  • Source: Healthy cynomolgus monkey
  • Purity: Free of foreign impurities.
  • Applications: Suitable for various research fields including biomarker research, pharmacology, and toxicology.
  • Storage Conditions: Store at -20 °C or -80 °C. Avoid freeze-thaw cycle.

Technical Specifications

  • Collection Method: Breast milk is collected from rigorously screened healthy donors, and the collection process strictly adheres to animal welfare requirements. Obtained milk does not contain contamination and serves as a primary source for biomarkers.
  • Quality Control: Strict accordance with biomedical standards.
  • Available Formats: Frozen
Downloadable Resources Published Data FAQs Customer Reviews
  • Cynomolgus Monkey Breast Milk (NHP-BF022) Data Sheet: Detailed information.

This paper evaluates the transfer of milk and toxicokinetics of Valproic Acid (VPA), an antiepileptic drug, dosed in various oral doses to Cynomolgus monkeys during days of lactation from Day 100 gestation to Day 31 lactation. In the present study, we have determined the concentrations of VPA and its metabolite 4-ene-VPA in maternal plasma, offspring plasma, and milk using liquid chromatography tandem mass spectrometry. Transfer via milk of VPA was observed, which shows that the offspring were exposed to the drug. The concentration of VPA in milk increased with dosage, while 4-ene-VPA was detected in very low concentrations. This study points out the importance of proper understanding of the transfer of drugs via breast milk in the non-human primate model, which has close physiological similarities with humans and thus would provide information concerning the risks and safety of drugs during lactation.

Schematic representation of the milk transfer study incynomolgus monkeys.1Fig. 1. Schematic representation of the milk transfer study incynomolgus monkeys.

Concentrations of valproic acid (VPA) in maternal plasma, milk and pup's plasma.1Fig. 2. Concentrations of valproic acid (VPA) in maternal plasma, milk and pup's plasma.

Concentrations of 4-ene valproic acid (4-ene-VPA) in maternal plasma, milk and pup's plasma.1Fig. 3. Concentrations of 4-ene valproic acid (4-ene-VPA) in maternal plasma, milk and pup's plasma.

Reference

  1. Reference: Edward Koo., et al. " Milk Transfer and Toxicokinetics of Valproic Acid in Lactating Cynomolgus Monkeys." Toxicol Res. 29, 53-60 (2013).
  1. Q 1: How does the nutritional profile of Cynomolgus Monkey Breast Milk compare to that of humans?

    A: The nutritional profiling of Cynomolgus Monkey Breast Milk closely resembles and is different from that of human breast milk. Such comparisons are great needs to know the lactation biology of primates and can, in turn, be informative both for infant nutrition and possible supplementation with formula during certain cases.

  2. Q 2: What are the ethical considerations in collecting Cynomolgus Monkey Breast Milk for research?

    A: Ethical collection should mean that stress and harm to the animals in the process are minimized from Cynomolgus Monkey Breast Milk. It must be guided by stringent ethical guidelines and under surveillance by animal care committees, which keep the interest of the animals first while facilitating the accomplishment of valuable biomedical research.

  • Very Satisfied
    The Cynomolgus Monkey Breast Milk received from Creative Biolabs was essential in the execution of our comparative lactation studies. The quality of the product received and the information regarding ethical sourcing made us feel pretty comfortable about the company's quality and sensitivity towards animal welfare.

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