GJA1 Polyclonal Antibody (NHP-AB352)

• This product is an antibody that was generated by immunizing rabbit against a peptide located in the C-Terminal domain of GJA1 (Human). It is used only in in vitro assays.

Detailed Product Description

• Introduction: GJA1 is a member of the gap junction protein family. Connexins assemble as a hexamer and are transported to the plasma membrane to create a hemichannel that can associate with hemichannels on nearby cells to create cell-to-cell channels. Clusters of these channels assemble to make gap junctions. Gap junction communication is important in development and regulation of cell growth. Phosphorylation of GJA1 is important in regulating assembly and function of gap junctions. Ser368 of GJA1 is phosphorylated by protein kinase C (PKC) after activation by phorbol esters, which decreases cell-to-cell communication. Src can interact with and phosphorylate GJA1 to alter gap junction communication. GFAP are membrane-spanning proteins that facilitate the transfer of ions and small molecules between cells.
• Conjugate: None
• Applications: IHC

Technical Specifications

• Host Species: Rabbit
• Species Reactivity: Bovine; Dog; Gibbon; Gorilla; Guinea Pig; Hamster; Human; Monkey; Mouse; Pig; Rabbit; Rat
• Immunogen: A peptide located in the C-Terminal domain of GJA1 (Human)

Product Property

• Purification: Immunoaffinity Chromatography
• Format: Liquid
• Concentration: 0.2 mg/mL
• Buffer: PBS, 0.1% sodium azide
• Storage: Short term: 4˚C. Long term: Store at -20˚C.

Target Information

• Clonality: Polyclonal
• Alternative Names: alpha 1 connexin; connexin 43; Connexin-43; Cx-43; Cx43; CXA1; DFNB38; Gap junction 43 kDa heart protein; Gap junction alpha-1 protein; gap junction membrane channel protein alpha 1; gap junction protein, alpha 1, 43kDa; ODD; ODOD; SDTY3; Syndactyly type III
• Entrez Gene ID: 2697