LAG-3 (CD223) Monoclonal Antibody (SP38) (NHP-AB223)

• This product is an antibody that was generated by immunizing mouse against recombinant human LAG-3. It is used only in in vitro assays.

Detailed Product Description

• Introduction: LAG-3 is a 70-kDa surface glycoprotein belonging to the Ig superfamily with homology to CD4. LAG-3 binds to MHC class II with higher affinity than CD4 and is thought to be involved in the negative regulation of T cell activation and homeostatic proliferation. Surface expression of LAG-3 has been reported on activated T cells (including regulatory T cells) and NK cells. CD8+ T cells usually express LAG-3 at significantly higher levels than CD4+ T cells. Coexpression of LAG-3 and CD49b has been proposed to identify human and mouse Type 1 regulatory T cells (Tr1 cells).
• Conjugate: None
• Antibody Isotype: IgG1
• Applications: ELISA; Func; ICC; IHC; IP; WB

Technical Specifications

• Host Species: Mouse
• Species Reactivity: Human; Monkey
• Immunogen: Recombinant human LAG-3

Product Property

• Purification: SDS-PAGE
• Format: Liquid
• Concentration: 0.5 mg/mL
• Buffer: Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
• Storage: Store at -20⁰C for at least 1 year.

Target Information

• Target: LAG-3
• Clone: SP38
• Clonality: Monoclonal
• Alternative Names: Activation-induced cytidine deaminase-linked autoimmunity protein; Aida; CD223; LAG-3; Lymphocyte activation gene 3 protein; Secreted lymphocyte activation gene 3 protein; sLAG 3; sLAG-3; sLAG3; soluble LAG 3; lymphocyte activating 3; soluble LAG3
• Entrez Gene ID: 3902