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Phenobarbital (PB) Treated Cynomolgus Monkey Liver Microsomes (NHP-CM004)
Category:Non-Human Primate (NHP) Microsome Products
Tag: Cynomolgus monkey, Microsomes
Tag: Cynomolgus monkey, Microsomes
- Liver microsomes are essentially subcellular particles, which are isolated from hepatic cells' ER organelles and are mainly applied to conduct metabolite identification, reaction phenotyping, intrinsic clearance, and inhibition research. The liver microsome products offered by Creative Biolabs are obtained from cynomolgus monkeys treated with phenobarbital (PB), which are of high quality and are equipped with high levels of CYP2A and CYP2B, coumarin 7-hydroxylation, and testosterone 16β-hydroxylation.
Detailed Product Description
- Source: Liver
- Applications: Used in studies on metabolite ID, reaction phenotyping, intrinsic clearance and inhibition.
- Storage: -80°C
Technical Specifications
- Species: Cynomolgus monkey
- Donor Status: Healthy
- Quality Control: Quality control processes are strictly implemented to ensure the quality and consistency.
- Shipping: Dry ice
Downloadable Resources
FAQs
Customer Reviews
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Q 1: How do phenobarbital-treated cynomolgus monkey liver microsomes compare to human liver microsomes in terms of drug metabolism and enzyme activity?
A: Phenobarbital-treated cynomolgus monkey liver microsomes are often utilized as a model for studying drug metabolism due to their enzyme induction characteristics, which can mimic hepatic enzyme induction in humans. Researchers are particularly interested in the cytochrome P450 family of enzymes, which play a significant role in the metabolism of drugs. These microsomes can offer insights into potential drug-drug interactions, enzyme kinetics, and metabolic stability, though there may be species-specific differences that need to be accounted for when extrapolating data to humans.
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Q 2: What are the key considerations when using phenobarbital-treated cynomolgus monkey liver microsomes in preclinical research?
A: When using phenobarbital-treated cynomolgus monkey liver microsomes in preclinical research, several considerations need to be taken into account:
Species Differences: While cynomolgus monkeys are a valuable model due to their physiological similarities to humans, there are still species-specific differences that could impact the translation of results.
Phenobarbital Induction: The induction of enzymes by phenobarbital may differ in rate and extent between cynomolgus monkeys and humans, which can affect drug metabolism and the prediction of in vivo human responses.
Experimental Design: Appropriate controls and replicates are critical to ensure robust and reproducible results. Factors such as the age, sex, and health status of the donor monkeys can influence microsomal enzyme activity.
Regulatory Approvals: The use of non-human primates in research comes with ethical considerations and requires adherence to regulatory guidelines for ethical treatment and us
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Exceptional Quality
As a pharmacologist involved in drug metabolism studies, I used the Phenobarbital (PB) Treated Cynomolgus Monkey Liver Microsomes from Creative BioLabs for my recent research. The quality of the microsomes was exceptional, with consistent and reliable enzyme activity. It was apparent that the monkeys were appropriately treated with Phenobarbital, as evidenced by the high levels of cytochrome P450 enzymes. This greatly facilitated our study on drug-drug interactions and metabolic pathways. The detailed documentation and support provided were also very helpful, making the entire process smooth. I highly recommend this product for any in-depth pharmacokinetic studies. -
Robust and Reproducible Results
I was looking for high-quality liver microsomes for my research on hepatic enzyme induction and phenobarbital's effects on enzyme activity. The products from Creative BioLabs met my expectations. The liver microsomes from Phenobarbital-treated Cynomolgus monkeys provided robust and reproducible results. They helped us elucidate the metabolic profile of several new drug candidates. While the overall experience with the product was positive, the shipment took a bit longer than expected due to some customs clearance issues. Nonetheless, I am satisfied with the microsomal enzyme activity and would recommend it to other researchers in the field of drug metabolism and pharmacokinetics.
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NHP Biologicals from Creative Biolabs are for research, diagnostic, or manufacturing purposes only. They may not be intended for or are not approved for any other use.
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