- This product is an antibody that was generated by immunizing mouse against PHA stimulated human peripheral blood lymphocytes. It is used only in in vitro assays.
Detailed Product Description
- Introduction: Semaphorins are neuronal chemorepellants that direct pioneering neurons during nervous system development. CD100 (also known as semaphorin 4d), a 150 kDa homodimer, is a novel semaphorin that induces B cells to aggregate and improves their viability in vitro. CD100 modifies CD40-CD40L B cell signaling by augmenting B cell aggregation and survival and down regulating CD23 expression. CD72 is a lymphocyte receptor for the class IV semaphorin CD100, which is involved in regulating B cell signaling. CD100 is expressed on resting and PHA stimulated T cells. The protein is weakly expressed on NK cells, EBV transformed B cells, monocytes and tumor/peripheral blood T cell lines, and at higher density on activated T cells and B cells.
- Conjugate: None
- Antibody Isotype: IgMκ
- Applications: Flow Cytometry; IF
Technical Specifications
- Host Species: Mouse
- Species Reactivity: Baboon; Human
- Immunogen: PHA stimulated human peripheral blood lymphocytes
Product Property
- Format: Liquid
- Concentration: 0.2 mg/mL
- Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
- Storage: Store at 4⁰C.
Target Information
- Target: Semaphorin-4D
- Clone: V23U9
- Clonality: Monoclonal
- Alternative Names: A8; BB18; CD100; GR3; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D; Semaphorin-4D
- Entrez Gene ID: 10507
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