- This product is an antibody that was generated by immunizing mouse against a synthetic peptide corresponding to amino acids 563 - 577 of TBK1 (Human). It is used only in in vitro assays.
Detailed Product Description
- Introduction: Nuclear factor kappa B (NF-KB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-KB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-KB is associated with IKB proteins in the cell cytoplasm, which inhibit NF-KB activity. Phosphorylation of I-KB by IKB kinase (IKK) complex leads to degradation of I-KB and activation of NF-KB. The IKK complex contains IKKa, IKKβ, and IKKK. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-KB-activating kinase), and T2K. NAK/TBK1 activates IKKβ through direct phosphorylation. NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors. NAK/TBK1 functions upstream of NIK and the IKK complex. NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.
- Conjugate: None
- Antibody Isotype: IgG1κ
- Applications: IHC; WB
Technical Specifications
- Host Species: Mouse
- Species Reactivity: Bovine; Dog; Gibbon; Gorilla; Hamster; Horse; Human; Monkey; Mouse; Pig; Rabbit; Rat
- Immunogen: A synthetic peptide corresponding to amino acids 563 - 577 of TBK1 (Human)
Product Property
- Purification: Protein G Column
- Format: Liquid
- Concentration: 1 mg/mL
- Buffer: PBS, 0.2% gelatin, 0.05% sodium azide.
- Storage: Short term: 4˚C. Long term: Store at -20˚C. Avoid freeze-thaw cycles.
Target Information
- Clone: A2R5
- Clonality: Monoclonal
- Alternative Names: FLJ11330; NF-kappa-B-activating kinase; NF-kB-activating kinase; serine/threonine protein kinase TBK1; Serine/threonine-protein kinase TBK1; T2K; TANK-binding kinase 1; tbk
- Entrez Gene ID: 29110
Downloadable Resources
Customer Reviews
There are currently no customer reviews or questions for TBK1 Monoclonal Antibody (A2R5) (NHP-AB249). Click the button below to contact us or submit your feedback about this product.
Related Products
Online Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
NHP Biologicals from Creative Biolabs are for research, diagnostic, or manufacturing purposes only. They may not be intended for or are not approved for any other use.
Enter your email here to subscribe.
SubmitFollow us on
Copyright © 2024 Creative Biolabs. All rights reserved.