MMP9-expressing Oncolytic Herpes Simplex Virus 1 (ΔΔICP0), CMV-MMP9(Cat#: CyOV-0049XY)
DatasheetThis product is a MMP9 expressing oncolytic herpes simplex virus, which is based on HSV-1 with ICP0 deleted. The deletion of ICP0 were attenuated for viral growth, and impaired for viral reactivation when equivalent latent infections were established in vivo. This product can be used in oncolytic virotherapy research and further recombinant HSV construction.
Specifications | |
|---|---|
| Family | Herpesviridae |
| Species | Herpes simplex virus |
| Serotype | Herpes simplex virus 1 |
| Backbone | HSV-1 (ΔΔICP0) |
| Backbone Background | Herpes simplex virus 1 and 2 (HSV-1 and HSV-2), also known as human herpesvirus 1 and 2 (HHV-1 and HHV-2), are two members of the human Herpesviridae family, a set of viruses that produce viral infections in the majority of humans. Modified Herpes simplex virus is considered as a potential therapy for cancer and has been extensively clinically tested to assess its oncolytic ability. |
| Gene Modification | ΔΔICP0 |
| Promoter | CMV |
| Transgene | MMP9 |
| Type of Transgene | Cytokine |
| Related Target/Protein | Matrix metallopeptidase 9 |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Osteosarcoma |
Transgene | |
|---|---|
| Alternative Names | MMP9, GELB, CLG4B, MMP-9, MANDP2, matrix metallopeptidase 9 |
| Gene ID | 4318 |
Information | |
|---|---|
| Introduction | Matrix metallopeptidase 9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), is a matrixin, a class of enzymes that belong to the zinc-metalloproteinases family involved in the degradation of the extracellular matrix. In humans the MMP9 gene encodes for a signal peptide, a propeptide, a catalytic domain with inserted three repeats of fibronectin type II domain followed by a C-terminal hemopexin-like domain. |
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