CXCL13-expressing Oncolytic Vaccinia Virus Western Reserve (ΔE3L), p11k-CXCL13(Cat#: CyOV-0011WQ)
DatasheetThis product is a CXCL13 expressing oncolytic vaccinia virus, which is based on VACV-WR with E3L deleted.CXCL13 is selectively chemotactic for B cells belonging to both the B-1 and B-2 subsets, and elicits its effects by interacting with chemokine receptor CXCR5. The deletion of E3L and CXCL13 expression could enhance the immune activity. This product can be used in oncolytic virotherapy research and vaccinie application.
Specifications | |
|---|---|
| Family | Poxviridae |
| Species | Vaccinia virus |
| Serotype | Western Reserve |
| Backbone | VACV-WR(ΔE3L) |
| Backbone Background | VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies. |
| Gene Modification | ΔE3L |
| Promoter | p11k |
| Transgene | CXCL13 |
| Type of Transgene | Cytokine |
| Related Target/Protein | C-X-C motif chemokine ligand 13 |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Mammary tumor |
Transgene | |
|---|---|
| Alternative Names | BLC; BCA1; ANGIE; BCA-1; BLR1L; ANGIE2; SCYB13 |
| Gene ID | 10563 |
| UniProt ID | O43927 |
Information | |
|---|---|
| Introduction | B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. |
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