GM-CSF-expressing Oncolytic Vaccinia Virus Western Reserve (ΔE3L), pSE-GMCSF(Cat#: CyOV-0018WQ)
DatasheetThis product is a GM-CSF expressing oncolytic vaccinia virus, which is based on VACV-WR with E3L deleted.The GM-CSF is a monomeric glycoprotein that functions as a cytokine-it is a white blood cell growth factor.The deletion of E3L and GM-CSF expression could enhance the immune activity. This product can be used in oncolytic virotherapy research and vaccinie application.
Specifications | |
|---|---|
| Family | Poxviridae |
| Species | Vaccinia virus |
| Serotype | Western Reserve |
| Backbone | VACV-WR(ΔE3L) |
| Backbone Background | VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies. |
| Gene Modification | ΔE3L |
| Promoter | pSE |
| Transgene | GM-CSF |
| Type of Transgene | Cytokine |
| Related Target/Protein | Granulocyte-macrophage colony-stimulating factor |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Melanoma, Breast Cancer |
Information | |
|---|---|
| Introduction | Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. |
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All products and services are for Research Use Only. Not For Clinical Use.
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