IL-2-expressing Oncolytic Vaccinia Virus Western Reserve (ΔK3L), p11k-(IL-2)(Cat#: CyOV-0111WQ)
DatasheetThis product is a IL-2 expressing oncolytic vaccinia virus, which is based on VACV-WR with K3L deleted. IL-2 has essential roles in key functions of the immune system, tolerance and immunity, primarily via its direct effects on T cells. The deletion of K3L and IL-2 expressing could enhance the immune activity. This product can also be used in oncolytic virotherapy research and vaccinie application.
Specifications | |
|---|---|
| Family | Poxviridae |
| Species | Vaccinia virus |
| Serotype | Western Reserve |
| Backbone | VACV-WR(ΔK3L) |
| Backbone Background | VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies. |
| Gene Modification | ΔK3L |
| Promoter | p11k |
| Transgene | IL-2 |
| Type of Transgene | Cytokine |
| Related Target/Protein | Interleukin 2 |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Colon cancer |
Information | |
|---|---|
| Introduction | The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. |
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