mCCL2-expressing Oncolytic Vaccinia Virus Western Reserve (ΔE3L), pSE/L-mCCL2(Cat#: CyOV-0064WQ)
DatasheetThis product is a CCL2 expressing oncolytic vaccinia virus, which is based on VACV-WR with E3L deleted.The CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. The deletion of E3L and CCL2 expressing could enhance the immune activity. This product can also be used in oncolytic virotherapy research and vaccinie application.
Specifications | |
|---|---|
| Family | Poxviridae |
| Species | Vaccinia virus |
| Serotype | Western Reserve |
| Backbone | VACV-WR(ΔE3L) |
| Backbone Background | VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies. |
| Gene Modification | ΔE3L |
| Promoter | pSE/L |
| Transgene | mCCL2 |
| Type of Transgene | Cytokine |
| Related Target/Protein | C-C motif chemokine ligand 2 |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Tumor |
Transgene | |
|---|---|
| Alternative Names | HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30 |
| Gene ID | 6347 |
| UniProt ID | P13500 |
Information | |
|---|---|
| Introduction | This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. |
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