GFP-encoding Oncolytic Vaccinia Virus Western Reserve (ΔK3L), p11k-(GFP)(Cat#: RepOV-0033WQ)
DatasheetThis product is a GFP encoding oncolytic vaccinia virus, which is based on VACV-WR with K3L deleted. Binding of CXCL10 to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. The deletion of K3L and CXCL10 expression could enhance the immune activity. This product can be used in oncolytic virotherapy research and vaccinie application.
Specifications | |
|---|---|
| Family | Poxviridae |
| Species | Vaccinia virus |
| Serotype | Western Reserve |
| Backbone | VACV-WR(ΔK3L) |
| Backbone Background | VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies. |
| Gene Modification | ΔK3L |
| Promoter | p11k |
| Transgene | GFP |
| Type of Transgene | Reporter gene |
| Related Target/Protein | Green fluorescent protein |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Breast cancer, Prostate cancer, Colon cancer, Cancer vaccine |
Information | |
|---|---|
| Introduction | The green fluorescent protein (GFP) is a protein composed of 238 amino acid residues (26.9 kDa) that exhibits bright green fluorescence when exposed to light in the blue to ultraviolet range. Although many other marine organisms have similar green fluorescent proteins, GFP traditionally refers to the protein first isolated from the jellyfish Aequorea victoria. The GFP from A. victoria has a major excitation peak at a wavelength of 395 nm and a minor one at 475 nm. Its emission peak is at 509 nm, which is in the lower green portion of the visible spectrum. The fluorescence quantum yield (QY) of GFP is 0.79. The GFP from the sea pansy (Renilla reniformis) has a single major excitation peak at 498 nm. GFP makes for an excellent tool in many forms of biology due to its ability to form internal chromophore without requiring any accessory cofactors, gene products, or enzymes / substrates other than molecular oxygen. |
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