lacZ-encoding Oncolytic Vaccinia Virus Western Reserve (ΔK3L), pSL-(lacZ)(Cat#: RepOV-0058WQ)
DatasheetThis product is a lacZ encoding oncolytic vaccinia virus, which is based on VACV-WR with K3L deleted. Binding of CXCL10 to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. The deletion of K3L and CXCL10 expression could enhance the immune activity. This product can be used in oncolytic virotherapy research and vaccinie application.
Specifications | |
|---|---|
| Family | Poxviridae |
| Species | Vaccinia virus |
| Serotype | Western Reserve |
| Backbone | VACV-WR(ΔK3L) |
| Backbone Background | VACV-WR strain derived from Wyeth through passaging in mice and shown high tumor selectivity and strong oncolytic effect in mouse models.The engineered VACV-WR could further enhance the immune activity and the efficacy of cancer therapies. |
| Gene Modification | ΔK3L |
| Promoter | pSL |
| Transgene | lacZ |
| Type of Transgene | Reporter gene |
| Related Target/Protein | Beta-galactosidase |
| Capsid Modification | None |
| Titer | >1*10^8 PFU |
| Related Diseases | Breast cancer, Prostate cancer, Colon cancer, Cancer vaccine |
Transgene | |
|---|---|
| Alternative Names | lacZ, b0344, ECK0341, beta-galactosidase |
| Gene ID | 945006 |
| UniProt ID | P00722 |
Information | |
|---|---|
| Introduction | The lac operon (lactose operon) is an operon required for the transport and metabolism of lactose in Escherichia coli and many other enteric bacteria. The gene product of lacZ is β-galactosidase which cleaves lactose, a disaccharide, into glucose and galactose. |
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All products and services are for Research Use Only. Not For Clinical Use.
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