DBCO-PEG4-DBCO (CAT#: ADC-L-336)

Product Information

CAS NO
2182601-68-7

Molecular Weight
811

Purity
95%

Formula
C48H50N4O8

Group 1
DBCO

Click Chemistry Group 1
DBCO

PEG/Non-PEG
PEG

Cleavable/Non-cleavable
Non-cleavable

Storage Condition
-20 ° C

Shipping
Ambient Temperature

For Research Use Only. NOT FOR CLINICAL USE.

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Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform

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Customer Reviews FAQ

Excellent

DBCO-PEG4-DBCO was very effective in our bioconjugation experiments, allowing us to link two molecules efficiently. The PEG4 linker provided enough flexibility to avoid steric hindrance, and the results were highly reproducible.

Excellent

In our ADC research, DBCO-PEG4-DBCO proved invaluable. The dual DBCO groups allowed for precise crosslinking, and the PEG4 chain minimized aggregation, enhancing the stability of the drug conjugates.

Excellent

DBCO-PEG4-DBCO worked flawlessly for crosslinking applications. The PEG4 linker offered the necessary flexibility, ensuring that the conjugation between molecules proceeded smoothly and efficiently, with minimal side reactions.

Excellent

When used in an ADC project, DBCO-PEG4-DBCO enabled high-efficiency payload conjugation with antibodies. The PEG4 chain provided the flexibility needed for optimal binding without compromising solubility.

Excellent

DBCO-PEG4-DBCO made a significant difference in our drug development experiments, especially in ADC projects. The dual DBCO groups enabled effective payload attachment while the PEG4 chain provided enhanced flexibility and solubility.

Q: 1: How does DBCO-PEG4-DBCO function in ADC development?
A: DBCO-PEG4-DBCO facilitates the conjugation of two biomolecules with azide groups through strain-promoted azide-alkyne cycloaddition (SPAAC), making it useful for site-specific conjugation in ADCs.
Q: 2: What services does Creative Biolabs provide for DBCO-PEG4-DBCO applications?
A: Creative Biolabs offers custom bioconjugation services using DBCO-PEG4-DBCO, including linker optimization, conjugation strategies, and in vitro / in vivo testing for ADC development and other therapeutic applications.
Q: 3: What is the purpose of having two DBCO groups in DBCO-PEG4-DBCO?
A: The dual DBCO groups enable the simultaneous conjugation of two azide-functionalized molecules, providing flexibility in designing multifunctional drug conjugates or linking different biomolecules.
Q: 4: Can DBCO-PEG4-DBCO be used in multifunctional ADCs?
A: Yes, DBCO-PEG4-DBCO allows for the attachment of multiple payloads to an antibody, facilitating the design of multifunctional ADCs with enhanced therapeutic effects.
Q: 5: What concentrations of DBCO-PEG4-DBCO are typically used in conjugation reactions?
A: Concentrations of DBCO-PEG4-DBCO vary depending on the application, but they typically range from micromolar to millimolar levels to achieve efficient crosslinking in bioconjugation experiments.

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