DBCO-SS-NHS (CAT#: ADC-L-904)

DBCO-SS-NHS is a cleavable disulfide linker for bio-conjugation that contains a terminal DBCO group and a terminal NHS group.

Product Information

Description
DBCO-SS-NHS is a cleavable disulfide linker for bio-conjugation that contains a terminal DBCO group and a terminal NHS group.

Molecular Weight
565.7

Purity
95%

For Research Use Only. NOT FOR CLINICAL USE.

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Customer Reviews FAQ

Excellent

Creative Biolabs' DBCO-SS-NHS was highly efficient in our bioconjugation experiments. The product enabled reliable and stable conjugation with excellent results in antibody labeling. A versatile tool for our research needs.

Excellent

DBCO-SS-NHS from Creative Biolabs performed flawlessly in our experiments. The cleavable disulfide linker worked perfectly, enabling precise and controlled conjugation. We achieved consistent and reproducible results with this product.

Excellent

We utilized DBCO-SS-NHS from Creative Biolabs for site-specific bioconjugation and were impressed by its stability and performance. The product allowed smooth conjugation, contributing to the success of our labeling assays.

Excellent

Creative Biolabs' DBCO-SS-NHS showed great reactivity and was easy to use in our click chemistry-based experiments. The disulfide bond cleaved efficiently, making it ideal for our bioconjugation projects.

Excellent

Creative Biolabs' DBCO-SS-NHS offered excellent results in our bioconjugation assays. The product's stability and efficient release of the conjugates provided reliable and repeatable results, making it a top choice for our projects.

Q: 1: What is DBCO-SS-NHS used for in biological research?
A: DBCO-SS-NHS is used for bioconjugation, enabling the attachment of biomolecules, such as proteins or antibodies, to other molecules via amine-reactive NHS ester and azide-reactive DBCO groups, commonly in click chemistry applications.
Q: 2: How does DBCO-SS-NHS function in bioconjugation?
A: The NHS ester in DBCO-SS-NHS reacts with primary amines, forming stable amide bonds, while the DBCO group allows azide-click reactions, enabling efficient conjugation without the need for copper catalysts.
Q: 3: What are the common applications of DBCO-SS-NHS in research?
A: DBCO-SS-NHS is widely used in bioconjugation, antibody labeling, and protein-protein interactions. It enables the attachment of biomolecules to surfaces or other molecules in various bioorthogonal chemistry applications
Q: 4: What is the role of the disulfide bond in DBCO-SS-NHS?
A: The disulfide (SS) bond in DBCO-SS-NHS allows for potential cleavability, enabling the release of conjugated molecules under reducing conditions, such as in intracellular environments, where reducing agents are present.
Q: 5: How can Creative Biolabs' DBCO-SS-NHS improve conjugation efficiency?
A: Creative Biolabs offers high-purity DBCO-SS-NHS with enhanced reactivity and stability, ensuring efficient and reproducible bioconjugation for a wide range of bioorthogonal chemistry applications.

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