1. Home
  2. Products
  3. Customized ADCs
  4. ERBB2
  5. Anti-ERBB2 (Pertuzumab)-MC-MMAF ADC

Anti-ERBB2 (Pertuzumab)-MC-MMAF ADC (CAT#: ADC-W-1114)

This ADC product is comprised of an anti-ERBB2 monoclonal antibody conjugated via a MC linker to MMAF. The MMAF is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAF binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Name
  • ERBB2
  • Alternative Names
  • ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); NGL, v erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog); receptor tyrosine-prܰɫࢸง݌ɵࣛ฾ݩɿࣽ๵ކʈटຬޣʒू໤޿ʜ।༛ߜʥআདྷ߹ʯ঩ྉࠕʹো࿁࠲˂৭࿸ࡏˌਐု࡬˖ਲၦ࢈˟੔႞ࢥ˩੷ვࣂ˳ઙᄌࣟ˼઻ᅃࣻ̆૞ᅻघ̐଀ᆲव̙ଢᇩ॒̣୅ሠ८̭୧ቘঋ̶உ኏ন̀஬዆৅͊௎ዽৡ͓௰ጵ৾͝ఓ፬ਛͧవᎣਸͰ౗Ꮪ੔ͺ౺ᐑੱ΄ಜᑉ઎΍ಾᒀફΗೡᒷેΡഃᓮ૤Ϊഥᔦଁδൈᕝଞξ൪ᖔ଺χඌᗋୗϑදᘃ୴ϛෑᘺஐϤෳᙱ஭Ϯถᚨொϸุᛠ௧Ё๛᜗ఃЋ๽ᝎఠЕຟចఽПໂួౚШ໤៴౶в༆ᠫಓм༩ᡢರхཋᢚ್я཭ᣑ೩љྐᤈആѢྲ᤿ണѬ࿔᥷ീѶ࿷᦮൜ѿမ᧥൹҉ျ᨜ඖғၞᩓඳҜႀ᪋ාҦႢ᫂෬ҰჅ᫹ฉҹყᬰฦӃᄉ᭨โӍᄬᮟ๟Ӗᅎᯖ๼ӠᅰᰍນӪᆓ᱅ີӳᆵᱼ໒ӽᇗᲳ໯ԇᇺᳪ༌Ԑሜᴢ༨ԚሾᵙཅԤቡᶐརԭኃ᷇ཾԷእ᷿ྛՁወḶྸՊዪṭ࿕ՔጌẤ࿱՞ጯỜဎէፑἓါձ፳Ὂ၈ջ᎖ᾁၤքᎸᾹႁ֎Ꮫ῰႞֘ᏽ‧Ⴛ֢ᐟ⁞თ֫ᑂₕჴֵᑤ⃍ᄑֿᒆ℄ᄮ׈ᒩ℻ᅊגᓋⅲᅧלᓭ↪ᆄץᔐ⇡ᆡׯᔲ∘ᆽ׹ᕔ≏ᇚ؂ᕷ⊇ᇷ،ᖙ⊾ሔؖᖻ⋵ሰ؟ᗞ⌬ቍةᘀ⍤ቪسᘢ⎛ኇؼᙅ⏒ኣنᙧ␉ዀِᚉ⑁ዝٙᚬ⑸ዺ٣ᛎ
  • Target Entrez Gene ID
  • 2064
  • Overview
  • This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
  • Overview
  • Humanized Anti-ERBB2 IgG1-kappa antibody, Pertuzumab
  • Generic name
  • Pertuzumab
  • Host animal
  • Mouse
  • Species Reactivity
  • Human
  • Name
  • MC (maleimidocaproyl)
  • Description
  • Noncleavable linkers, is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
  • Name
  • MMAF
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

Related Products

Published Data

+ Submit Publications

Submit a review or a question

Scientific Resources

CAMouse™-Fully Human Antibody Generation Platform
Reviews
Development of Monoclonal Antibodies
Literature
CAMouse™-Fully Human Antibody Generation Platform
Protocol

Customer Reviews and FAQs

There are currently no Customer reviews or questions for ADC-W-1114. Click the button above to contact us or submit your feedback about this product.

Quick Links

ADC Toxins
Drug-linker Complexes
Customized ADCs
Anti-Ab ADCs

Other Products

Same Target Same Linker Same Payload
CAT# Product Name Linker Payload
ADC-W-1113 Anti-ERBB2 (Pertuzumab)-SPDB-DM4 ADC SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
ADC-W-2597 Anti-ERBB2 (Trastuzumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA
ADC-W-2595 Anti-ERBB2 (Trastuzumab)-SPDB-DM4 ADC SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
ADC-W-1117 Anti-ERBB2 (Pertuzumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA
ADC-W-582 Anti-ERBB2-SMCC-DM1 ADC SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine)
CAT# Product Name Linker Payload
ADC-W-518 Anti-TM4SF1 ( clone 2A7A)-Mc-LP2 ADC Mc (maleimidocaproyl) LP2 (chemical name mc-3377)
ADC-W-537 Anti-TPBG-Mc-MMAF ADC Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F)
ADC-W-515 Anti-EGFR (ABT-806)-Mc-MMAF ADC Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F)
ADC-W-2622 Anti-NCAM1 (Lorvotuzumab )-MC-MMAF ADC MC (maleimidocaproyl) MMAF
ADC-W-452 Anti-CD70 (clone 1F6)-Mc-MMAF ADC Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F)
CAT# Product Name Linker Payload
ADC-AA-064 Anti-HIgG(Fab)-C-MMAF ADC Cleavable linkers MMAF
ADC-W-2622 Anti-NCAM1 (Lorvotuzumab )-MC-MMAF ADC MC (maleimidocaproyl) MMAF
ADC-W-2585 Anti-EGFR (Zalutumumab)-MC-MMAF ADC MC (maleimidocaproyl) MMAF
ADC-W-2550 Anti-CD74-MC-MMAF ADC MC (maleimidocaproyl) MMAF
ADC-W-2544 Anti-CD44 (Bivatuzumab)-MC-MMAF ADC MC (maleimidocaproyl) MMAF

Online Inquiry

Name:
*Phone:
*E-mail Address:
*Products or Services Interested:
Company/Institution
Project Description:

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.